2021
Circulating Fatty Acids Associated with Advanced Liver Fibrosis and Hepatocellular Carcinoma in South Texas Hispanics
Jiao J, Kwan S, Sabotta C, Tanaka H, Veillon L, Warmoes M, Lorenzi P, Wang Y, Wei P, Hawk E, Almeda J, McCormick J, Fisher-Hoch S, Beretta L. Circulating Fatty Acids Associated with Advanced Liver Fibrosis and Hepatocellular Carcinoma in South Texas Hispanics. Cancer Epidemiology Biomarkers & Prevention 2021, 30: 1643-1651. PMID: 34155064, PMCID: PMC8419070, DOI: 10.1158/1055-9965.epi-21-0183.Peer-Reviewed Original ResearchConceptsAdvanced liver fibrosisNonalcoholic fatty liver diseaseLiver fibrosisHepatocellular carcinomaFree fatty acidsVLC nPlasma concentrationsCameron County Hispanic CohortFatty liver diseaseLiver fibrosis progressionRelatives of patientsStrong predictive factorLow plasma concentrationsSecond-degree relativesLiver fibrosis severityOdd-chain SFAsTexas HispanicsVLC-SFAFIB-4Advanced fibrosisLiver diseaseNAFLD progressionFibrosis progressionN3-PUFAsFatty acids
2017
Prevalence of Aflatoxin-associated TP53R249S mutation in Hepatocellular Carcinoma in Hispanics in South Texas
Jiao J, Niu W, Wang Y, Baggerly K, Ye Y, Wu X, Davenport D, Almeda J, Betancourt-Garcia M, Forse R, Stevenson H, Watt G, McCormick J, Fisher-Hoch S, Beretta L. Prevalence of Aflatoxin-associated TP53R249S mutation in Hepatocellular Carcinoma in Hispanics in South Texas. Cancer Prevention Research 2017, 11: 103-112. PMID: 29089331, PMCID: PMC5811406, DOI: 10.1158/1940-6207.capr-17-0235.Peer-Reviewed Original ResearchConceptsAdvanced fibrosisHepatocellular carcinomaCell-free DNAHCC patientsHispanic subjectsShorter overall survivalPlasma cell-free DNAAsian HCC patientsOverall survivalWorse prognosisAflatoxin exposureHigh incidenceCirrhosisHCC tumorsPromising biomarkerDietary exposureFibrosisYounger agePatientsDroplet digital PCRHispanicsSomatic mutationsFamily membersUpstream regulatorSubjects