2018
Telomerase reverse transcriptase mutations in plasma DNA in patients with hepatocellular carcinoma or cirrhosis: Prevalence and risk factors
Jiao J, Watt G, Stevenson H, Calderone T, Fisher‐Hoch S, Ye Y, Wu X, Vierling J, Beretta L. Telomerase reverse transcriptase mutations in plasma DNA in patients with hepatocellular carcinoma or cirrhosis: Prevalence and risk factors. Hepatology Communications 2018, 2: 718-731. PMID: 29881823, PMCID: PMC5983165, DOI: 10.1002/hep4.1187.Peer-Reviewed Original ResearchEvidence of HCCHepatitis C virusReverse transcriptase mutationsCell-free DNAHepatocellular carcinomaMale patientsTranscriptase mutationsLong-term imaging surveillancePlasma cell-free DNAFrequent genetic alterationsAlcoholic cirrhosisCancer Genome AtlasImaging surveillanceT promoter mutationClinical parametersMale sexPoor prognosisC virusRisk factorsSimilar prevalenceEarly biomarkersFamily historyHigh prevalenceCirrhosisPatientsDepletion of S100A4+ stromal cells does not prevent HCC development but reduces the stem cell-like phenotype of the tumors
Jiao J, González Á, Stevenson H, Gagea M, Sugimoto H, Kalluri R, Beretta L. Depletion of S100A4+ stromal cells does not prevent HCC development but reduces the stem cell-like phenotype of the tumors. Experimental & Molecular Medicine 2018, 50: e422-e422. PMID: 29303514, PMCID: PMC5992984, DOI: 10.1038/emm.2017.175.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinoma, HepatocellularCell DifferentiationGene Expression Regulation, NeoplasticHepatitisHepatocytesLiver NeoplasmsLiver Neoplasms, ExperimentalMice, KnockoutMice, TransgenicNeoplastic Stem CellsNon-alcoholic Fatty Liver DiseasePTEN PhosphohydrolaseS100 Calcium-Binding Protein A4Stromal CellsConceptsDepletion of S100A4Hepatocellular carcinomaMouse modelCalcium-binding protein S100A4Stromal cellsStemness phenotypeDevelopment of HCCOval cell hyperplasiaReduction of inflammationStemness propertiesCell stemness propertiesNew mouse modelStem cell-like phenotypeViral thymidine kinaseCell-like phenotypeLiver diseaseCell hyperplasiaPoor prognosisGanciclovir injectionsNAS scoreAdjacent liverGastric cancerHCC developmentProtein S100A4Hepatic deletion
2015
miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells
Zhang J, Jiao J, Cermelli S, Muir K, Jung K, Zou R, Rashid A, Gagea M, Zabludoff S, Kalluri R, Beretta L. miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells. Cancer Research 2015, 75: 1859-1867. PMID: 25769721, PMCID: PMC4603420, DOI: 10.1158/0008-5472.can-14-1254.Peer-Reviewed Original ResearchConceptsCancer-associated stromal cellsLiver fibrosisMiR-21Liver cancerProgenitor cellsStromal cellsTumor developmentAssociated liver fibrosisPrevents tumor developmentLiver tumor growthLiver progenitor cellsPreclinical evidenceIntrahepatic cholangiocarcinomaPoor prognosisChemopreventive targetHepatocellular carcinomaHepatic deletionNotch2 inhibitionTumor growthMalignant developmentFibrosisInducing ApoptosisIntegrin αvCancerCell survival