Abrogation of skin disease in LUPUS‐prone MRL/FASlpr mice by means of a novel tylophorine analog
Choi J, Gao W, Odegard J, Shiah H, Kashgarian M, McNiff JM, Baker DC, Cheng Y, Craft J. Abrogation of skin disease in LUPUS‐prone MRL/FASlpr mice by means of a novel tylophorine analog. Arthritis & Rheumatism 2006, 54: 3277-3283. PMID: 17009262, DOI: 10.1002/art.22119.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusEnd-organ diseaseInflammatory skin diseaseMRL/Skin diseasesMRL/Faslpr miceFemale MRL/NF-kappaB inhibitorFlow cytometric analysisFaslpr miceAutoantibody titersIgG levelsLupus erythematosusLymph nodesRenal diseaseVehicle treatmentKidney diseaseHepatic toxicityTotal IgMTylophorine analogsAntichromatin autoantibodiesTherapeutic effectHistopathologic analysisMurine modelSignificant abrogationCD40 ligation of rheumatoid synovial fibroblasts regulates RANKL‐medicated osteoclastogenesis: Evidence of NF‐κB–dependent, CD40‐mediated bone destruction in rheumatoid arthritis
Lee H, Jeon H, Song E, Han M, Park S, Lee S, Yun H, Kim J, Kim J, Lee Y, Kim S, Kim H, Choi J, Kang I, Kim H, Yoo W. CD40 ligation of rheumatoid synovial fibroblasts regulates RANKL‐medicated osteoclastogenesis: Evidence of NF‐κB–dependent, CD40‐mediated bone destruction in rheumatoid arthritis. Arthritis & Rheumatism 2006, 54: 1747-1758. PMID: 16736517, DOI: 10.1002/art.21873.Peer-Reviewed Original ResearchMeSH KeywordsArthritis, RheumatoidCarrier ProteinsCD40 AntigensCells, CulturedFibroblastsHumansI-kappa B KinaseI-kappa B ProteinsMembrane GlycoproteinsMitogen-Activated Protein Kinase 1NF-kappa BNF-KappaB Inhibitor alphaOsteoclastsP38 Mitogen-Activated Protein KinasesRANK LigandReceptor Activator of Nuclear Factor-kappa BReverse Transcriptase Polymerase Chain ReactionSynovial MembraneConceptsRheumatoid arthritis synovial fibroblastsRANKL expressionCD40 ligationSynovial fibroblastsT cellsIkappaB-alphaNF-kappaBPeripheral blood mononuclear cellsTumor necrosis factor alphaTartrate-resistant acid phosphatase (TRAP) stainingERK 1/2CD40-CD40L interactionBlood mononuclear cellsRheumatoid synovial fibroblastsArthritis synovial fibroblastsNecrosis factor alphaP38 MAPKReverse transcription-polymerase chain reactionResorption pit formationNF-kappaB inhibitorTranscription-polymerase chain reactionFormation of osteoclastsNF-kappaB activationAcid phosphatase stainingL cells