2019
HLA-C variants associated with amino acid substitutions in the peptide binding groove influence susceptibility to Kawasaki disease
Shimizu C, Kim J, Eleftherohorinou H, Wright V, Hoang L, Tremoulet A, Franco A, Hibberd M, Takahashi A, Kubo M, Ito K, Tanaka T, Onouchi Y, Coin L, Levin M, Burns J, Shike H, Consortium O. HLA-C variants associated with amino acid substitutions in the peptide binding groove influence susceptibility to Kawasaki disease. Human Immunology 2019, 80: 731-738. PMID: 31122742, PMCID: PMC10793643, DOI: 10.1016/j.humimm.2019.04.020.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAmino Acid SequenceAmino Acid SubstitutionAntigen PresentationBinding SitesCohort StudiesGene FrequencyGenetic Predisposition to DiseaseGenotypeHistocompatibility TestingHLA-C AntigensHumansJapanMucocutaneous Lymph Node SyndromePeptidesPolymorphism, Single NucleotideProtein BindingProtein DomainsT-Lymphocytes, CytotoxicConceptsKawasaki diseaseCytotoxic T cellsSusceptible childrenJapanese cohortRisk A-alleleSingle cohort studyHLA class ISingle nucleotide variantsHLA-C variantsHLA-B geneCohort studyPediatric vasculitisAmino acid substitutionsT cellsKD susceptibilityHLAUnknown triggerA alleleRisk allelesClass ICohortInfluence susceptibilityAcid substitutionsNon-conservative amino acid substitutionsVasculitis
2017
ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesions
Eckert M, Santiago-Medina M, Lwin T, Kim J, Courtneidge S, Yang J. ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesions. Journal Of Cell Science 2017, 130: 2036-2048. PMID: 28468988, PMCID: PMC5482979, DOI: 10.1242/jcs.198200.Peer-Reviewed Original ResearchMeSH KeywordsADAM12 ProteinAnimalsBreast NeoplasmsCell AdhesionCell LineCell Line, TumorCell MovementCell SizeCells, CulturedEpithelial-Mesenchymal TransitionExtracellular MatrixFemaleFocal AdhesionsGene Expression Regulation, NeoplasticHEK293 CellsHumansMammary Neoplasms, AnimalMiceMutagenesis, Site-DirectedNeoplasm InvasivenessNeoplasm MetastasisNeoplasm TransplantationNuclear ProteinsProtein DomainsSignal TransductionTwist-Related Protein 1ConceptsFocal adhesionsEpithelial-mesenchymal transitionMetalloproteinase domainOverall cell adhesionFocal adhesion turnoverRegulation of invadopodiaMammary organoid culturesLive-imaging analysisTwist1 transcription factorMatrix degradationTumor invasionAdhesion turnoverPrimary tumor formationExtracellular matrix degradationInvadopodia formationTranscription factorsTranscription targetsInvadopodiaCell invasionBreast cancer cellsCell adhesionExpression levelsTumor formationPromotes Tumor InvasionCancer cells