ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesions
Eckert M, Santiago-Medina M, Lwin T, Kim J, Courtneidge S, Yang J. ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesions. Journal Of Cell Science 2017, 130: 2036-2048. PMID: 28468988, PMCID: PMC5482979, DOI: 10.1242/jcs.198200.Peer-Reviewed Original ResearchMeSH KeywordsADAM12 ProteinAnimalsBreast NeoplasmsCell AdhesionCell LineCell Line, TumorCell MovementCell SizeCells, CulturedEpithelial-Mesenchymal TransitionExtracellular MatrixFemaleFocal AdhesionsGene Expression Regulation, NeoplasticHEK293 CellsHumansMammary Neoplasms, AnimalMiceMutagenesis, Site-DirectedNeoplasm InvasivenessNeoplasm MetastasisNeoplasm TransplantationNuclear ProteinsProtein DomainsSignal TransductionTwist-Related Protein 1ConceptsFocal adhesionsEpithelial-mesenchymal transitionMetalloproteinase domainOverall cell adhesionFocal adhesion turnoverRegulation of invadopodiaMammary organoid culturesLive-imaging analysisTwist1 transcription factorMatrix degradationTumor invasionAdhesion turnoverPrimary tumor formationExtracellular matrix degradationInvadopodia formationTranscription factorsTranscription targetsInvadopodiaCell invasionBreast cancer cellsCell adhesionExpression levelsTumor formationPromotes Tumor InvasionCancer cellsExtracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood
Eguchi A, Lazaro R, Wang J, Kim J, Povero D, Willliams B, Ho S, Stärkel P, Schnabl B, Ohno‐Machado L, Tsukamoto H, Feldstein A. Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood. Hepatology 2017, 65: 475-490. PMID: 27639178, PMCID: PMC5407075, DOI: 10.1002/hep.28838.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnalysis of VarianceAnimalsBiopsy, NeedleCells, CulturedDisease Models, AnimalExtracellular VesiclesFatty Liver, AlcoholicHepatocytesHumansImmunoblottingImmunohistochemistryMiceMicroRNAsMiddle AgedRandom AllocationReal-Time Polymerase Chain ReactionSampling StudiesSeverity of Illness IndexStatistics, NonparametricYoung AdultConceptsBlood extracellular vesiclesLiver injuryExtracellular vesiclesNuclear factor kappa BAlcoholic liver diseaseChronic liver injuryWeeks of infusionBile duct ligationB-cell lymphoma 2Levels of EVsFactor kappa BSteatohepatitis developmentNonalcoholic steatohepatitisLiver diseaseObese miceHepatic macrophagesDuct ligationKappa BMiR-340Cell originLymphoma 2Intragastric infusionMiceMiRNA signatureTime points