2019
Expression of the type 3 InsP3 receptor is a final common event in the development of hepatocellular carcinoma
Guerra MT, Florentino RM, Franca A, Lima Filho AC, Dos Santos ML, Fonseca RC, Lemos FO, Fonseca MC, Kruglov E, Mennone A, Njei B, Gibson J, Guan F, Cheng YC, Ananthanarayanan M, Gu J, Jiang J, Zhao H, Lima CX, Vidigal PT, Oliveira AG, Nathanson MH, Leite MF. Expression of the type 3 InsP3 receptor is a final common event in the development of hepatocellular carcinoma. Gut 2019, 68: 1676. PMID: 31315892, PMCID: PMC7087395, DOI: 10.1136/gutjnl-2018-317811.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsApoptosisCalcium SignalingCarcinogenesisCarcinoma, HepatocellularCell ProliferationCells, CulturedDNA MethylationFemaleGene Expression Regulation, NeoplasticHepatocytesHumansInositol 1,4,5-Trisphosphate ReceptorsLiverLiver NeoplasmsLiver RegenerationMaleMice, KnockoutMiddle AgedSurvival AnalysisConceptsChronic liver diseaseITPR3 expressionLiver cancer cellsLiver diseaseMouse modelFinal common eventCancer cellsSpecimens of patientsIndependent patient cohortsControl liver specimensHuman HCC cellsType 3 InsP3 receptorHuman liver samplesIncreased expression levelCancer deathPatient cohortCommon molecular eventPoor survivalHepatocellular carcinomaLiver specimensNormal liverHCC cellsAbstractTextHCCType 3 isoform
2015
Identification of cancer‐related genes and motifs in the human gene regulatory network
Carson M, Gu J, Yu G, Lu H. Identification of cancer‐related genes and motifs in the human gene regulatory network. IET Systems Biology 2015, 9: 128-134. PMID: 26243828, PMCID: PMC8687282, DOI: 10.1049/iet-syb.2014.0058.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceChromosome MappingGene Expression Regulation, NeoplasticGenes, NeoplasmGenetic Predisposition to DiseaseHumansMolecular Sequence DataMultigene FamilyNeoplasmsNucleotide MotifsTranscription Factors
2014
A three‐gene panel that distinguishes benign from malignant thyroid nodules
Zheng B, Liu J, Gu J, Lu Y, Zhang W, Li M, Lu H. A three‐gene panel that distinguishes benign from malignant thyroid nodules. International Journal Of Cancer 2014, 136: 1646-1654. PMID: 25175491, DOI: 10.1002/ijc.29172.Peer-Reviewed Original ResearchAdultAgedBiomarkers, TumorCarbonic AnhydrasesDatasets as TopicDiagnosis, DifferentialDipeptidyl Peptidase 4FemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleMiddle AgedNeuroendocrine Secretory Protein 7B2PrognosisReproducibility of ResultsThyroid NeoplasmsThyroid NoduleYoung AdultMulticlass classification of sarcomas using pathway based feature selection method
Gu J, Lu Y, Liu C, Lu H. Multiclass classification of sarcomas using pathway based feature selection method. Journal Of Theoretical Biology 2014, 362: 3-8. PMID: 25014475, DOI: 10.1016/j.jtbi.2014.06.038.Peer-Reviewed Original Research