LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy
Chen Y, Jiang T, Zhang H, Gou X, Han C, Wang J, Chen AT, Ma J, Liu J, Chen Z, Jing X, Lei H, Wang Z, Bao Y, Baqri M, Zhu Y, Bindra RS, Hansen JE, Dou J, Huang C, Zhou J. LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy. Nature Cell Biology 2020, 22: 1276-1285. PMID: 33005030, PMCID: PMC7962994, DOI: 10.1038/s41556-020-00586-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisAtaxia Telangiectasia Mutated ProteinsBrain NeoplasmsBreast NeoplasmsCell ProliferationDNA DamageDNA RepairFemaleGamma RaysHumansMiceMice, Inbred BALB CMice, NudeMutS Homolog 2 ProteinNuclear ProteinsPhosphorylationRadiation-Sensitizing AgentsSignal TransductionTumor Cells, CulturedXenograft Model Antitumor AssaysTargeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids
Li S, Su W, Wu H, Yuan T, Yuan C, Liu J, Deng G, Gao X, Chen Z, Bao Y, Yuan F, Zhou S, Tan H, Li Y, Li X, Fan L, Zhu J, Chen AT, Liu F, Zhou Y, Li M, Zhai X, Zhou J. Targeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids. Nature Biomedical Engineering 2020, 4: 704-716. PMID: 32231314, PMCID: PMC7197249, DOI: 10.1038/s41551-020-0540-y.Peer-Reviewed Original ResearchConceptsAmino acid transporter 1Orthotopic mouse modelHuman tumor xenograftsLarge neutral amino acid transporter 1Neutral amino acid transporter 1High tumor selectivityTumor burdenMouse modelTumor xenograftsHuman gliomasDetectable toxicityTransporter 1TumorsCancer cellsTumor selectivitySurface moleculesDelivery of chemotherapeuticsTumor-specific imagingMiceDrugsLarge amino acidsAmino acidsImagingDeliveryXenografts