2020
LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy
Chen Y, Jiang T, Zhang H, Gou X, Han C, Wang J, Chen AT, Ma J, Liu J, Chen Z, Jing X, Lei H, Wang Z, Bao Y, Baqri M, Zhu Y, Bindra RS, Hansen JE, Dou J, Huang C, Zhou J. LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy. Nature Cell Biology 2020, 22: 1276-1285. PMID: 33005030, PMCID: PMC7962994, DOI: 10.1038/s41556-020-00586-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisAtaxia Telangiectasia Mutated ProteinsBrain NeoplasmsBreast NeoplasmsCell ProliferationDNA DamageDNA RepairFemaleGamma RaysHumansMiceMice, Inbred BALB CMice, NudeMutS Homolog 2 ProteinNuclear ProteinsPhosphorylationRadiation-Sensitizing AgentsSignal TransductionTumor Cells, CulturedXenograft Model Antitumor Assays
2007
Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance
Zhou J, Wulfkuhle J, Zhang H, Gu P, Yang Y, Deng J, Margolick JB, Liotta LA, Petricoin E, Zhang Y. Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 16158-16163. PMID: 17911267, PMCID: PMC2042178, DOI: 10.1073/pnas.0702596104.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBreast NeoplasmsCell CycleCell Line, TumorCell SurvivalFemaleHumansMiceMice, NudeModels, BiologicalNeoplasm TransplantationNeoplastic Stem CellsOligonucleotide Array Sequence AnalysisProtein KinasesPTEN PhosphohydrolaseSignal TransductionSTAT3 Transcription FactorTOR Serine-Threonine KinasesConceptsCancer stem-like cellsStem-like cellsNon-SP cellsSP cellsATP-binding cassette (ABC) transportersTarget of rapamycinActivator of transcriptionCDNA microarray analysisPathway-specific inhibitorsSTAT3 pathwayVivo tumorigenicity assaysProtein microarray technologyRare cell populationsCytometry cell cycle analysisSide population cellsColony formation abilityMTOR/STAT3 pathwayCell maintenanceSignal transductionBreast cancer stem-like cellsGene knockdownNegative regulatorCassette transportersMicroarray analysisCell cycle analysis