2014
Inhibition of striatal‐enriched tyrosine phosphatase 61 in the dorsomedial striatum is sufficient to increased ethanol consumption
Darcq E, Hamida SB, Wu S, Phamluong K, Kharazia V, Xu J, Lombroso P, Ron D. Inhibition of striatal‐enriched tyrosine phosphatase 61 in the dorsomedial striatum is sufficient to increased ethanol consumption. Journal Of Neurochemistry 2014, 129: 1024-1034. PMID: 24588427, PMCID: PMC4055745, DOI: 10.1111/jnc.12701.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DrinkingAnimalsAntibodies, BlockingBlotting, WesternChoice BehaviorDown-RegulationEnzyme InhibitorsGene Knockdown TechniquesImmunohistochemistryLentivirusMaleMiceMice, Inbred C57BLMotor ActivityNeostriatumPhosphorylationProtein Tyrosine PhosphatasesQuinineRNA, Small InterferingSaccharin
2008
Expression and function of striatal enriched protein tyrosine phosphatase is profoundly altered in cerebral ischemia
Braithwaite SP, Xu J, Leung J, Urfer R, Nikolich K, Oksenberg D, Lombroso PJ, Shamloo M. Expression and function of striatal enriched protein tyrosine phosphatase is profoundly altered in cerebral ischemia. European Journal Of Neuroscience 2008, 27: 2444-2452. PMID: 18445231, PMCID: PMC2738830, DOI: 10.1111/j.1460-9568.2008.06209.x.Peer-Reviewed Original ResearchConceptsStriatal enriched protein tyrosine phosphataseProtein tyrosine phosphataseTyrosine phosphatasePost-transcriptional levelNovel speciesPhosphorylation stateImportant proteinsMature formKey substrateNMDA receptor subunitsReceptor subunitsActive formSynaptic functionComplex cascadeCritical roleERKMRNA levelsProteinMRNAPERKPhosphataseCleavageCentral nervous systemNervous systemSubunits