2013
Striatal-Enriched Protein Tyrosine Phosphatase—STEPs Toward Understanding Chronic Stress-Induced Activation of Corticotrophin Releasing Factor Neurons in the Rat Bed Nucleus of the Stria Terminalis
Dabrowska J, Hazra R, Guo JD, Li C, DeWitt S, Xu J, Lombroso PJ, Rainnie DG. Striatal-Enriched Protein Tyrosine Phosphatase—STEPs Toward Understanding Chronic Stress-Induced Activation of Corticotrophin Releasing Factor Neurons in the Rat Bed Nucleus of the Stria Terminalis. Biological Psychiatry 2013, 74: 817-826. PMID: 24012328, PMCID: PMC3818357, DOI: 10.1016/j.biopsych.2013.07.032.Peer-Reviewed Original ResearchConceptsStriatal-enriched protein tyrosine phosphataseLong-term potentiationProtein tyrosine phosphataseCRF neuronsReverse transcriptase-polymerase chain reactionTranscriptase-polymerase chain reactionRestraint stressTyrosine phosphatasePolymerase chain reactionBed nucleusFactor neuronsStria terminalisWhole-cell patch-clamp electrophysiologyInduction of LTPRole of STEPQuantitative reverse transcriptase-polymerase chain reactionChain reactionNovel treatment strategiesStress-induced anxiety disordersAnxiety-like behaviorSingle-cell reverse transcriptase-polymerase chain reactionPatch-clamp electrophysiologyStress-Induced ActivationRat bed nucleusTyrosine phosphatase STEP
2012
The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications
Carty NC, Xu J, Kurup P, Brouillette J, Goebel-Goody SM, Austin DR, Yuan P, Chen G, Correa PR, Haroutunian V, Pittenger C, Lombroso PJ. The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications. Translational Psychiatry 2012, 2: e137-e137. PMID: 22781170, PMCID: PMC3410627, DOI: 10.1038/tp.2012.63.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptorsSTEP61 levelsSurface expressionPostmortem anterior cingulate cortexGluN2B-containing N-methyl-D-aspartate receptorsGluN1/GluN2B receptorsMK-801 treatmentPathophysiology of schizophreniaAnterior cingulate cortexSTEP knockout miceDorsolateral prefrontal cortexChronic administrationChronic treatmentNeuroleptic treatmentAntipsychotic medicationGlutamatergic functionMK-801Glutamate hypothesisMedications resultsTyrosine phosphatase STEPGlutamatergic signalingKnockout miceGluN2B receptorsCingulate cortexSynaptic plasticity