Sustained High‐Dose Nitroglycerin Transcutaneous Patch Therapy in Angina Pectoris: Evidence for Attenuation of Effect Over Time
Frishman W, Giles T, Greenberg S, Heiman M, Raffidal L, Soberman J, Laifer L, Nadelmann J, Lazar E, Strom J. Sustained High‐Dose Nitroglycerin Transcutaneous Patch Therapy in Angina Pectoris: Evidence for Attenuation of Effect Over Time. The Journal Of Clinical Pharmacology 1989, 29: 1097-1105. PMID: 2515215, DOI: 10.1002/j.1552-4604.1989.tb03285.x.Peer-Reviewed Original ResearchConceptsPlasma nitroglycerin levelsWeek 1Blood pressurePatch therapyHeart rateSerial treadmill testingChronic stable anginaDouble-blind fashionSystolic blood pressureHigher plasma levelsAttenuation of effectsDrug-free baselineIntolerable headacheMg/24 hoursMmHg reductionTitration doseDosing intervalExercise toleranceStable anginaAngina pectorisPlacebo patchTreadmill testingSublingual nitroglycerinPlasma levelsVenous blood