Lamotrigine–valproic acid combination therapy for medically refractory epilepsy
Moeller JJ, Rahey SR, Sadler RM. Lamotrigine–valproic acid combination therapy for medically refractory epilepsy. Epilepsia 2008, 50: 475-479. PMID: 19054403, DOI: 10.1111/j.1528-1167.2008.01866.x.Peer-Reviewed Original ResearchConceptsEpilepsy typeRefractory epilepsyAntiepileptic drugsCombination therapyPatient demographicsBaseline seizure frequencyRetrospective chart reviewPrimary outcome measureInclusion-exclusion criteriaVPA monotherapyChart reviewSeizure frequencyRetrospective studyMedical intractabilityClinic databaseUnimproved patientsOutcome measuresPatientsTherapyEpilepsyDemographicsSignificant differencesSeizuresMonthsSeverity