2021
Lack of Guideline-Directed Medical Therapy in Patients Undergoing Endovascular Procedures for Critical Limb Ischemia
Llanos-Chea F, Jelani QU, Trejo-Paredes C, Curtis JP, Parzynski CS, Huang J, Faridi KF, Turner J, Smolderen KG, Mena-Hurtado C. Lack of Guideline-Directed Medical Therapy in Patients Undergoing Endovascular Procedures for Critical Limb Ischemia. Journal Of The American College Of Cardiology 2021, 77: 1374-1375. PMID: 33706882, DOI: 10.1016/j.jacc.2020.12.063.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsCohort StudiesEndovascular ProceduresFemaleGuideline AdherenceHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIschemiaMaleMiddle AgedPeripheral Arterial DiseasePlatelet Aggregation InhibitorsImpact of insurance status on ICD implantation practice patterns: Insights from the NCDR ICD registry
Ahmed I, Merchant FM, Curtis JP, Parzynski CS, Lampert R. Impact of insurance status on ICD implantation practice patterns: Insights from the NCDR ICD registry. American Heart Journal 2021, 235: 44-53. PMID: 33503408, DOI: 10.1016/j.ahj.2021.01.016.Peer-Reviewed Original ResearchConceptsOptimal medical therapyInsurance statusNCDR ICD RegistryMedical therapyComplication rateICD RegistryUninsured patientsCardiac resynchronization therapy defibrillatorPrivate insurancePropensity-weighted analysisSingle-chamber devicesPrimary preventionMean ageICD implantsPractice patternsTreatment weightingImplantation practicePatientsInverse probabilityTherapyInsurance coverageFurther studiesRegistryMedicareStatus
2019
Validating the use of registries and claims data to support randomized trials: Rationale and design of the Extending Trial-Based Evaluations of Medical Therapies Using Novel Sources of Data (EXTEND) Study
Strom JB, Tamez H, Zhao Y, Valsdottir LR, Curtis J, Brennan JM, Shen C, Popma JJ, Mauri L, Yeh RW. Validating the use of registries and claims data to support randomized trials: Rationale and design of the Extending Trial-Based Evaluations of Medical Therapies Using Novel Sources of Data (EXTEND) Study. American Heart Journal 2019, 212: 64-71. PMID: 30953936, PMCID: PMC6535119, DOI: 10.1016/j.ahj.2019.02.007.Peer-Reviewed Original ResearchConceptsMedical therapyDual Antiplatelet Therapy StudyEnd pointEnd-point eventsClinical trial programEfficacy of therapyPatient-level dataClinical trial dataHealth system dataUse of registriesNew medical treatmentsProcedural registryRandomized trialsClaims databasePatient populationNational registryAdministrative claimsOutcome dataMedical treatmentTrial programTrial dataRegistryTrial informationTherapy studiesTrial results
2014
Clinical Effectiveness of Cardiac Resynchronization Therapy Versus Medical Therapy Alone Among Patients With Heart Failure
Khazanie P, Hammill BG, Qualls LG, Fonarow GC, Hammill SC, Heidenreich PA, Al-Khatib SM, Piccini JP, Masoudi FA, Peterson PN, Curtis JP, Hernandez AF, Curtis LH. Clinical Effectiveness of Cardiac Resynchronization Therapy Versus Medical Therapy Alone Among Patients With Heart Failure. Circulation Heart Failure 2014, 7: 926-934. PMID: 25227768, PMCID: PMC4244212, DOI: 10.1161/circheartfailure.113.000838.Peer-Reviewed Original ResearchConceptsAcute Decompensated Heart Failure National RegistryImplantable Cardioverter-Defibrillator RegistryHeart failureMedical therapyCardiovascular readmissionCause readmissionQRS durationNational Cardiovascular Data Registry Implantable Cardioverter Defibrillator RegistryLeft ventricular ejection fractionCox proportional hazards modelHistorical control cohortOptimal medical therapyCardiac resynchronization therapyVentricular ejection fractionProportional hazards modelMultivariable adjustmentEjection fractionICD RegistryResynchronization therapyClinical effectivenessControl cohortNational registryClinical trialsLower riskHazards modelPrevalence of Guideline-Directed Medical Therapy Among Patients Receiving Cardiac Resynchronization Therapy Defibrillator Implantation in the National Cardiovascular Data Registry During the Years 2006 to 2008
Schneider PM, Pellegrini CN, Wang Y, Fein AS, Reynolds MR, Curtis JP, Masoudi FA, Varosy PD. Prevalence of Guideline-Directed Medical Therapy Among Patients Receiving Cardiac Resynchronization Therapy Defibrillator Implantation in the National Cardiovascular Data Registry During the Years 2006 to 2008. The American Journal Of Cardiology 2014, 113: 2052-2056. PMID: 24793671, PMCID: PMC4346333, DOI: 10.1016/j.amjcard.2014.03.049.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAged, 80 and overAngiotensin-Converting Enzyme InhibitorsCardiac Resynchronization TherapyCombined Modality TherapyDeath, Sudden, CardiacDefibrillators, ImplantableFemaleFollow-Up StudiesHeart FailureHumansMaleMiddle AgedPractice Guidelines as TopicPrevalenceRegistriesRetrospective StudiesRisk AssessmentSurvival AnalysisTreatment OutcomeUnited StatesVentricular Dysfunction, LeftConceptsGuideline-directed medical therapyCardiac resynchronization therapyImplantable Cardioverter-Defibrillator RegistryAngiotensin II receptor inhibitorΒ-blockersMedical therapyClass IReceptor inhibitorsNational Cardiovascular Data Registry Implantable Cardioverter Defibrillator RegistryCardiac resynchronization therapy defibrillator implantationLeft ventricular systolic dysfunctionSevere heart failure symptomsAngiotensin-converting enzyme inhibitorNational Cardiovascular Data RegistryClass I indicationsCRT-D implantationHeart failure symptomsVentricular systolic dysfunctionProportion of patientsSelection of patientsReal-world patientsAngiotensin-converting enzymePrevalence of guidelinesContemporaneous guidelinesQuality improvement targets
2013
Temporal Trends in Quality of Care Among Recipients of Implantable Cardioverter-Defibrillators
Dodson JA, Lampert R, Wang Y, Hammill SC, Varosy P, Curtis JP. Temporal Trends in Quality of Care Among Recipients of Implantable Cardioverter-Defibrillators. Circulation 2013, 129: 580-586. PMID: 24192798, PMCID: PMC3946506, DOI: 10.1161/circulationaha.113.003747.Peer-Reviewed Original ResearchConceptsOptimal medical therapyCardiac resynchronization therapyAdverse eventsEligible patientsQuality of careICD RegistryPotential confoundersNew York Heart Association class III/IVClass III/IVAngiotensin-converting enzyme inhibitorAngiotensin receptor blockersVentricular ejection fractionNew ICD implantsImplantable cardioverter defibrillatorHierarchical logistic regressionCRT eligibilityReceptor blockersEjection fractionMedical therapyResynchronization therapyICD implantsObservational studyCardioverter defibrillatorΒ-blockersPatients