Featured Publications
SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis
Zhou HJ, Xu Z, Wang Z, Zhang H, Zhuang Z, Simons M, Min W. SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis. Nature Communications 2018, 9: 3303. PMID: 30120232, PMCID: PMC6098000, DOI: 10.1038/s41467-018-05812-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCorneaCysteine EndopeptidasesDiabetes MellitusEndopeptidasesGene DeletionGene Knock-In TechniquesGene SilencingGolgi ApparatusHuman Umbilical Vein Endothelial CellsHumansIntracellular SpaceMaleMice, Inbred C57BLMice, KnockoutNeovascularization, PathologicProtein TransportRetinaSignal TransductionSUMO-1 ProteinSumoylationVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2ConceptsPathological angiogenesisPotential therapeutic targetRegulation of VEGFR2Non-sumoylated formEndothelial-specific deletionDiabetic miceHindlimb ischemiaTherapeutic targetDiabetic settingControl of angiogenesisEndothelial cellsAngiogenesisVEGFR2Surface expressionVEGFR2 activityTissue repairSENP1
2017
Stromal Senp1 promotes mouse early folliculogenesis by regulating BMP4 expression
Tan S, Feng B, Yin M, Zhou HJ, Lou G, Ji W, Li Y, Min W. Stromal Senp1 promotes mouse early folliculogenesis by regulating BMP4 expression. Cell & Bioscience 2017, 7: 36. PMID: 28770041, PMCID: PMC5526272, DOI: 10.1186/s13578-017-0163-5.Peer-Reviewed Original ResearchStromal cellsFollicle maturationPremature ovarian failureOvarian follicle developmentCell-specific deletionOocyte developmentOvarian failureFollicle numberSENP1 deficiencyOvarian folliclesEarly folliculogenesisDecreased expressionFollicle developmentEarly oocyte developmentGrowth factorRegulation of BMP4Oocyte growthFolliculogenesisMiceBMP4 expressionCre systemCellsMaturationSENP1Critical role