2020
Thiopental Does Not Produce Hyperalgesia: A Laboratory Study Using Two Human Experimental Pain Models
Arout CA, Petrakis IL, Ralevski E, Acampora G, Koretski J, DeNegre D, Newcomb J, Perrino AC. Thiopental Does Not Produce Hyperalgesia: A Laboratory Study Using Two Human Experimental Pain Models. Pain Medicine 2020, 21: 2823-2829. PMID: 32249311, PMCID: PMC8453625, DOI: 10.1093/pm/pnaa037.Peer-Reviewed Original ResearchConceptsArea of hyperalgesiaExperimental pain modelsCapsaicin conditionPain modelPain thresholdElectrical stimulationPercent changeHuman experimental pain modelsEffects of thiopentalVon Frey techniqueMcGill Pain QuestionnaireExperimental pain paradigmNoxious electrical stimulationSignificant differencesIntradermal capsaicinPain interpretationThiopental effectPain QuestionnaireBarbiturate administrationHyperalgesiaThiopental infusionHuman studiesPain paradigmPain toleranceElectrical stimulation currents
2016
Effect of Intravenous Ethanol on Capsaicin‐Induced Hyperalgesia in Human Subjects
Arout CA, Perrino AC, Ralevski E, Acampora G, Koretski J, Limoncelli D, Newcomb J, Petrakis IL. Effect of Intravenous Ethanol on Capsaicin‐Induced Hyperalgesia in Human Subjects. Alcohol Clinical And Experimental Research 2016, 40: 1425-1429. PMID: 27218476, PMCID: PMC4930397, DOI: 10.1111/acer.13095.Peer-Reviewed Original ResearchConceptsCapsaicin-induced hyperalgesiaVon Frey techniqueTime pointsArea of hyperalgesiaIntradermal capsaicin injectionExperimental pain paradigmVisual analog scaleAdditional outcome measuresImportant clinical implicationsTest dayETOH infusionHyperalgesia areasIntravenous EtOHAntihyperalgesic effectCentral sensitizationPrimary outcomeCapsaicin injectionChronic painPain processingAnalog scaleBreath alcohol concentrationIntravenous ethanolPain medicineHyperalgesiaOutcome measures