2024
Dexmedetomidine HCL (BXCL501) as a potential treatment for alcohol use disorder and comorbid PTSD: A phase 1b, placebo‐controlled crossover laboratory study
Petrakis I, Nolen T, Vandergrift N, Hirsch S, Krystal J, De Vivo M, Sabados J, Pisani E, Newcomb J, Kosten T. Dexmedetomidine HCL (BXCL501) as a potential treatment for alcohol use disorder and comorbid PTSD: A phase 1b, placebo‐controlled crossover laboratory study. American Journal On Addictions 2024 PMID: 39152094, DOI: 10.1111/ajad.13637.Peer-Reviewed Original ResearchPathophysiology of posttraumatic stress disorderAlcohol use disorderSubjective effects of alcoholEffects of alcoholUse disorderComorbid alcohol use disorderAlcohol cue reactivityPosttraumatic stress disorderCrossover laboratory studyCue reactivityAlcohol cravingNoradrenergic dysregulationStress disorderBlood pressureSubjective effectsEthanol administrationClinically significant adverse effectsPharmacotherapeutic approachesTest daysReceptor agonistsPotential treatmentDouble-blind fashionCravingDrinking alcoholDisorders
2023
Analysis of Drugs in Saliva of US Military Veterans Treated for Substance Use Disorders Using Supported Liquid Extraction and Surface-Enhanced Raman Spectral Analysis
Farquharson S, Shende C, Newcomb J, Petrakis I, Arias A. Analysis of Drugs in Saliva of US Military Veterans Treated for Substance Use Disorders Using Supported Liquid Extraction and Surface-Enhanced Raman Spectral Analysis. Molecules 2023, 28: 2010. PMID: 36903255, PMCID: PMC10004423, DOI: 10.3390/molecules28052010.Peer-Reviewed Original ResearchConceptsOpioid use disorderSubstance-related disordersUS military veteransUse disordersMilitary veteransDrug useIllicit drugsSubstance use disordersDrug overdose deathsIllicit drug useML of salivaBuprenorphine adherenceTreatment medicationsUrine testsOverdose deathsPatients' salivaDisease controlPatient samplesBuprenorphinePOC analyzerDrugsVulnerable populationsCare analyzerMedicationsDisorders
2020
Zonisamide as an Adjunctive Treatment to Cognitive Processing Therapy for Veterans With Posttraumatic Stress Disorder and Comorbid Alcohol Use Disorder: A Pilot Study
Petrakis I, Ralevski E, Arias AJ, DeNegre D, Newcomb J, Gianoli M, McCarthy E, Meshberg‐Cohen S, Yoon G. Zonisamide as an Adjunctive Treatment to Cognitive Processing Therapy for Veterans With Posttraumatic Stress Disorder and Comorbid Alcohol Use Disorder: A Pilot Study. American Journal On Addictions 2020, 29: 515-524. PMID: 32462773, DOI: 10.1111/ajad.13061.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAlcohol-Related DisordersAnticonvulsantsCognitive Behavioral TherapyCombined Modality TherapyDiagnosis, Dual (Psychiatry)Double-Blind MethodFeasibility StudiesFemaleHumansMaleMiddle AgedPatient SatisfactionPilot ProjectsStress Disorders, Post-TraumaticTreatment OutcomeVeterans HealthZonisamideConceptsAlcohol use disorderPosttraumatic stress disorderCognitive processing therapyComorbid alcohol use disorderSymptoms of PTSDUse disordersStress disorderPilot studyNonsignificant higher rateDouble-blind fashionReal-world treatmentCurrent alcohol dependenceEvidence-based psychotherapiesHigh rateAdjunctive treatmentPreliminary efficacyTreatment strategiesPsychosocial treatmentsPTSD outcomesZonisamideAlcohol dependencePlaceboLarger studyAlcohol useDisorders
2012
Subjective Effects of Thiopental in Young Adults with and without a Family History of Alcoholism
Petrakis IL, Kerfoot K, Pittman B, Perrino A, Koretski J, Newcomb J, Limoncelli D, Acampora G, Ralevski E. Subjective Effects of Thiopental in Young Adults with and without a Family History of Alcoholism. Journal Of Addiction Research & Therapy 2012, 2013 PMID: 24273687, PMCID: PMC3835602, DOI: 10.4172/2155-6105.s7-002.Peer-Reviewed Original ResearchAlcohol use disorderSubjective effectsUse disordersSub-anesthetic dosesAlcohol-related measuresSignificant main effectCognitive effectsAlcohol-like effectsFHN individualsSeparate test daysStimulant effectsYoung adultsCognitionMain effectSubjective responsesAlcohol dependenceTest dayFamily historyImpaired coordinationIndividualsResponse differencesFamily history-negative subjectsDisordersHealthy individualsFHP