2016
Hypochloremia, Diuretic Resistance, and Outcome in Patients With Acute Heart Failure
Ter Maaten JM, Damman K, Hanberg JS, Givertz MM, Metra M, O'Connor CM, Teerlink JR, Ponikowski P, Cotter G, Davison B, Cleland JG, Bloomfield DM, Hillege HL, van Veldhuisen DJ, Voors AA, Testani JM. Hypochloremia, Diuretic Resistance, and Outcome in Patients With Acute Heart Failure. Circulation Heart Failure 2016, 9: e003109. PMID: 27507112, DOI: 10.1161/circheartfailure.116.003109.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAgedAged, 80 and overBiomarkersChloridesDisease ProgressionDiureticsDown-RegulationDrug ResistanceFemaleHeart FailureHospitalizationHumansKaplan-Meier EstimateLinear ModelsMaleMiddle AgedMultivariate AnalysisProportional Hazards ModelsRisk FactorsTime FactorsTreatment OutcomeXanthinesConceptsAcute heart failureMEq/L.Heart failureDay 14Serum chloridePoor diuretic responseHours of admissionLower serum chlorideBlood urea nitrogenSerum chloride levelsAHF therapiesDiuretic resistancePROTECT trialNeurohormonal activationMultivariable adjustmentRenal functionHospital admissionMultivariable analysisDiuretic responseDiuretic responsivenessDiuretic targetChloride levelsUrea nitrogenHypochloremiaChloride homeostasisImportance of Abnormal Chloride Homeostasis in Stable Chronic Heart Failure
Grodin JL, Verbrugge FH, Ellis SG, Mullens W, Testani JM, Tang WH. Importance of Abnormal Chloride Homeostasis in Stable Chronic Heart Failure. Circulation Heart Failure 2016, 9: e002453. PMID: 26721916, PMCID: PMC4702267, DOI: 10.1161/circheartfailure.115.002453.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersChloridesChronic DiseaseCoronary AngiographyDown-RegulationFemaleHeart FailureHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisPrognosisProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsTime FactorsWater-Electrolyte BalanceWater-Electrolyte ImbalanceConceptsChronic heart failureStable chronic heart failureHeart failureLower serum chlorideSerum chlorideMortality riskElective diagnostic coronary angiographyLow serum chloride levelLong-term prognostic valueAdjusted mortality riskDiagnostic coronary angiographySerum chloride levelsAdjusted riskCause mortalityElectrolyte abnormalitiesCoronary angiographyStable patientsPrognostic implicationsPrognostic valueMultivariable modelChloride levelsSodium levelsPatientsChloride homeostasisMortality
2015
Perioperative heart-type fatty acid binding protein is associated with acute kidney injury after cardiac surgery
Schaub JA, Garg AX, Coca SG, Testani JM, Shlipak MG, Eikelboom J, Kavsak P, McArthur E, Shortt C, Whitlock R, Parikh CR. Perioperative heart-type fatty acid binding protein is associated with acute kidney injury after cardiac surgery. Kidney International 2015, 88: 576-583. PMID: 25830762, PMCID: PMC4556547, DOI: 10.1038/ki.2015.104.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAged, 80 and overBiomarkersCardiac Surgical ProceduresChi-Square DistributionFatty Acid Binding Protein 3Fatty Acid-Binding ProteinsFemaleHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisNorth AmericaOdds RatioPerioperative PeriodProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexUp-RegulationConceptsAcute kidney injurySevere acute kidney injuryCardiac surgeryKidney injuryKidney injury molecule-1Neutrophil gelatinase-associated lipocalinHeart-type fatty acid binding proteinAKI risk factorsInjury molecule-1Long-term mortalityBrain natriuretic peptideGelatinase-associated lipocalinH-FABP levelsMulti-center cohortTRIBE-AKI cohortFatty acid binding proteinLiver fatty acidHeart fatty acidCommon complicationSecondary outcomesSerum creatininePrimary outcomeInterleukin-18Risk stratificationCardiac injury
2014
The Incidence, Risk, and Consequences of Atrial Arrhythmias in Patients with Continuous‐Flow Left Ventricular Assist Devices
Brisco MA, Sundareswaran KS, Milano CA, Feldman D, Testani JM, Ewald GA, Slaughter MS, Farrar DJ, Goldberg LR, Investigators F. The Incidence, Risk, and Consequences of Atrial Arrhythmias in Patients with Continuous‐Flow Left Ventricular Assist Devices. Journal Of Cardiac Surgery 2014, 29: 572-580. PMID: 24750460, DOI: 10.1111/jocs.12336.Peer-Reviewed Original ResearchConceptsLeft ventricular assist deviceLate atrial arrhythmiaAtrial arrhythmiasVentricular assist deviceFunctional statusRisk factorsAssist deviceHeartMate II Left Ventricular Assist DeviceIncidence of AASix-minute walk distanceDestination therapy trialsDays of supportStrong risk factorQuality of lifePreoperative creatinineLVAD patientsSerum creatinineWalk distanceEjection fractionHeart failureLVAD supportQOL improvementMultivariable modelSimilar survivalBlanking period
2013
Cardiac transplantation can be safely performed using selected diabetic donors
Taghavi S, Jayarajan SN, Wilson LM, Komaroff E, Testani JM, Mangi AA. Cardiac transplantation can be safely performed using selected diabetic donors. Journal Of Thoracic And Cardiovascular Surgery 2013, 146: 442-447. PMID: 23490247, PMCID: PMC4067258, DOI: 10.1016/j.jtcvs.2013.02.047.Peer-Reviewed Original ResearchMeSH KeywordsAdultChi-Square DistributionDiabetes MellitusDonor SelectionFemaleHeart TransplantationHumansHypoglycemic AgentsInsulinKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisProportional Hazards ModelsRegistriesRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTissue and Organ ProcurementTissue DonorsTreatment OutcomeUnited StatesConceptsExtracorporeal membrane oxygenationBody mass indexDiabetic donorsCardiac transplantationIschemic timeMultivariate analysisHuman leukocyte antigen mismatchesDonor body mass indexHigher body mass indexRecipient black raceDuration of diabetesOrgan Sharing databaseInsulin-dependent diabetesAntigen mismatchesCardiac donorsRecipient creatinineRecipient diabetesMedian survivalMembrane oxygenationSharing databaseMass indexMechanical ventilationUnited NetworkRace mismatchBlack raceBlood Urea Nitrogen/Creatinine Ratio Identifies a High-Risk but Potentially Reversible Form of Renal Dysfunction in Patients With Decompensated Heart Failure
Brisco MA, Coca SG, Chen J, Owens AT, McCauley BD, Kimmel SE, Testani JM. Blood Urea Nitrogen/Creatinine Ratio Identifies a High-Risk but Potentially Reversible Form of Renal Dysfunction in Patients With Decompensated Heart Failure. Circulation Heart Failure 2013, 6: 233-239. PMID: 23325460, PMCID: PMC4067251, DOI: 10.1161/circheartfailure.112.968230.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiomarkersBlood Urea NitrogenCardio-Renal SyndromeChi-Square DistributionCreatinineFemaleGlomerular Filtration RateHeart FailureHumansKaplan-Meier EstimateKidneyLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioPatient AdmissionPrognosisProportional Hazards ModelsRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsUp-RegulationConceptsReversible renal dysfunctionBUN/CrBlood urea nitrogen/creatinine ratioUrea nitrogen/creatinine ratioHeart failureRenal functionRenal dysfunctionCreatinine ratioElevated BUN/CrPatients meeting eligibility criteriaDecompensated heart failure patientsDecompensated heart failureHigh-risk patientsHeart failure patientsGlomerular filtration rateRisk of deathMeeting eligibility criteriaConsecutive hospitalizationsBaseline characteristicsFailure patientsDischarge diagnosisFiltration rateEligibility criteriaPatientsReversible form
2011
Clinical Characteristics and Outcomes of Patients With Improvement in Renal Function During the Treatment of Decompensated Heart Failure
Testani JM, McCauley BD, Chen J, Coca SG, Cappola TP, Kimmel SE. Clinical Characteristics and Outcomes of Patients With Improvement in Renal Function During the Treatment of Decompensated Heart Failure. Journal Of Cardiac Failure 2011, 17: 993-1000. PMID: 22123361, PMCID: PMC3248245, DOI: 10.1016/j.cardfail.2011.08.009.Peer-Reviewed Original ResearchConceptsDecompensated heart failureRenal functionHeart failureRenal dysfunctionAcute decompensated heart failureVolume of diuresisOutcomes of patientsCongestive heart failureGlomerular filtration rateCardiorenal interactionsIRF patientsClinical characteristicsHemodynamic derangementsConsecutive patientsCardiac dysfunctionDischarge diagnosisPoor prognosisFiltration rateMortality riskEligibility criteriaPatientsGreater incidenceDysfunctionUniversity of PennsylvaniaIRF