2009
Peripheral glial cell differentiation from neurospheres derived from adipose mesenchymal stem cells
Radtke C, Schmitz B, Spies M, Kocsis J, Vogt P. Peripheral glial cell differentiation from neurospheres derived from adipose mesenchymal stem cells. International Journal Of Developmental Neuroscience 2009, 27: 817-823. PMID: 19699793, DOI: 10.1016/j.ijdevneu.2009.08.006.Peer-Reviewed Original ResearchConceptsMesenchymal stem cellsStem cellsGlial-like cellsAdipose-derived mesenchymal stem cellsGlial cell differentiationPeripheral glial cellsGrowth factorEpidermal growth factorGrowth factor receptorMitogen withdrawalFibroblast growth factorBasic fibroblast growth factorCell differentiationDorsal root ganglion neuronsSchwann cell marker S100P75 nerve growth factor receptorAdipose-derived stem cellsNerve growth factor receptorCellular aggregatesSimultaneous expressionOlfactory Ensheathing CellsAppropriate inductionFactor receptorNeurospheresGlia markers
2000
Excitability changes of dorsal root axons following nerve injury: implications for injury-induced changes in axonal Na+ channels
Nonaka T, Honmou O, Sakai J, Hashi K, Kocsis J. Excitability changes of dorsal root axons following nerve injury: implications for injury-induced changes in axonal Na+ channels. Brain Research 2000, 859: 280-285. PMID: 10719075, DOI: 10.1016/s0006-8993(00)01979-x.Peer-Reviewed Original ResearchConceptsDorsal root axonsNerve injuryDorsal rootsAction potentialsCutaneous afferent axonsSciatic nerve ligationAfferent cell bodiesInjury-induced changesRat dorsal rootSucrose gap chamberTarget disconnectionNerve ligationExcitability changesSpinal cordAfferent axonsTrophic supportRoot ligationRefractory periodCell bodiesElectrophysiological recordingsAxonsInjuryDepolarizationLigationPrevious studies
1991
Differential sensitivity to hypoxia of the peripheral versus central trajectory of primary afferent axons
Utzschneider D, Kocsis J, Waxman S. Differential sensitivity to hypoxia of the peripheral versus central trajectory of primary afferent axons. Brain Research 1991, 551: 136-141. PMID: 1913145, DOI: 10.1016/0006-8993(91)90924-k.Peer-Reviewed Original ResearchConceptsDorsal columnsDorsal rootsAfferent fibersCentral nervous system componentsPrimary afferent fibersSucrose gap chamberAction potential amplitudePrimary afferent axonsCompound action potentialDorsal spinal rootsNervous system componentsAxonal trunksPeripheral nervesSpinal cordSpinal rootsAfferent axonsCNS portionSchwann cellsAdult ratsPotential amplitudeAxon branchesAction potentialsHypoxiaMembrane potential changesMembrane depolarization
1988
Diminished dorsal root GABA sensitivity following chronic peripheral nerve injury
Kingery W, Fields R, Kocsis J. Diminished dorsal root GABA sensitivity following chronic peripheral nerve injury. Experimental Neurology 1988, 100: 478-490. PMID: 3366201, DOI: 10.1016/0014-4886(88)90033-7.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidPrimary afferent depolarizationDorsal rootsGABA sensitivityNerve lesionsSciatic nerveDorsal root compound action potentialsChronic peripheral nerve injurySciatic crush injurySciatic nerve lesionChronic pain syndromeLumbar dorsal rootsPeripheral nerve injuryPeripheral nerve lesionsPeripheral nerve transectionSucrose gap chamberCompound action potentialDorsal root fibersRat lumbar dorsal rootsDorsal root axotomyPain syndromeNerve injuryCrush injuryNerve transectionSciatic axotomy
1987
Axonal GABA receptors are selectively present on normal and regenerated sensory fibers in rat peripheral nerve
Bhisitkul R, Villa J, Kocsis J. Axonal GABA receptors are selectively present on normal and regenerated sensory fibers in rat peripheral nerve. Experimental Brain Research 1987, 66: 659-663. PMID: 3038587, DOI: 10.1007/bf00270698.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidVentral root fibersGABA receptorsRoot fibersSensory fibersPeripheral nervesSensory axonsRegenerated sensory axonsSucrose gap chamberPeripheral nerve fibersRat peripheral nerveDorsal root fibersMammalian peripheral nervesAgonist baclofenNerve crushDorsal rootsAgonist muscimolSciatic nerveNerve fibersRat peripheral nerve fibersNerveReceptorsMuscimolSelective presenceAxonsChapter 8 Ionic channel organization of normal and regenerating mammalian axons
Kocsis J, Waxman S. Chapter 8 Ionic channel organization of normal and regenerating mammalian axons. Progress In Brain Research 1987, 71: 89-101. PMID: 2438722, DOI: 10.1016/s0079-6123(08)61816-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsIon ChannelsMotor NeuronsNerve RegenerationNeurons, AfferentPeripheral NervesPotassiumSodiumConceptsNerve fibersPeripheral nervesRegenerated nerve fibersCell remodellingNormal developmentMammalian nerve fibresSchwann cellsElectrophysiological characteristicsFine caliberMyelinated axonsImmature axonsAxonal growthMammalian axonsNerveNormal maturationRemodelling occursAxonsCell arrestRemodellingTime courseMyelinIonic channelsLong termMaturationTime of maturation
1986
Action potential characteristics of demyelinated rat sciatic nerve following application of 4-aminopyridine
Targ E, Kocsis J. Action potential characteristics of demyelinated rat sciatic nerve following application of 4-aminopyridine. Brain Research 1986, 363: 1-9. PMID: 3004637, DOI: 10.1016/0006-8993(86)90652-9.Peer-Reviewed Original ResearchConceptsAction potentialsSciatic nerveFrequency-following abilityMultiple spike dischargesSite of demyelinationCompound action potentialPotassium channel blockerRat sciatic nerveAction potential characteristicsVariety of abnormalitiesAbsolute refractory periodExcitability changesPharmacological blockadeSpontaneous firingDemyelinated axonsChannel blockersConduction slowingConduction blockSpike dischargesLesion siteRefractory periodExcitability propertiesClinical useAxonsPotassium channels
1985
Myelin sheath remodelling in regenerated rat sciatic nerve
Hildebrand C, Kocsis J, Berglund S, Waxman S. Myelin sheath remodelling in regenerated rat sciatic nerve. Brain Research 1985, 358: 163-170. PMID: 2416385, DOI: 10.1016/0006-8993(85)90960-6.Peer-Reviewed Original ResearchConceptsRat sciatic nerveSciatic nerveRegenerated nervesAdult rat sciatic nerveRegenerated rat sciatic nerveNormal control nervesLight microscopic examinationAction potential waveformCrush lesionMonths survivalNerve segmentsControl nervesSame nerveIndividual nervesNerve fibersNerveShort sheathMyelin layersMyelin sheathPotassium channelsMicroscopic examinationLigature‐induced injury in peripheral nerve: Electrophysiological observations on changes in action potential characteristics following blockade of potassium conductance
Waxman S, Kocsis J, Eng D. Ligature‐induced injury in peripheral nerve: Electrophysiological observations on changes in action potential characteristics following blockade of potassium conductance. Muscle & Nerve 1985, 8: 85-92. PMID: 2414652, DOI: 10.1002/mus.880080202.Peer-Reviewed Original ResearchConceptsAction potentialsRepetitive firingSingle stimulusPotassium channelsCompound action potentialRat sciatic nerveAction potential propertiesWhole-nerve responseAction potential characteristicsIntra-axonal recordingsAction potential waveformNerve segmentsSciatic nerveNerve responsesPeripheral nervesInjury siteMyelinated fibersLater spikesElectrophysiological observationsNerveRefractory periodFiring patternsPotassium conductancePotential waveformInitial spike