1990
Elevated extracellular potassium concentration enhances synaptic activation of N-methyl-d-aspartate receptors in hippocampus
Poolos N, Kocsis J. Elevated extracellular potassium concentration enhances synaptic activation of N-methyl-d-aspartate receptors in hippocampus. Brain Research 1990, 508: 7-12. PMID: 2159824, DOI: 10.1016/0006-8993(90)91110-3.Peer-Reviewed Original ResearchConceptsNMDA receptor activationNMDA receptorsReceptor activationNMDA receptor-mediated componentN-methyl-D-aspartate receptorsElevated extracellular potassium concentrationReceptor-mediated componentReceptor-mediated conductanceChannel blocker tetraethylammoniumCentral nervous systemExtracellular potassium concentrationExtracellular potassium ion concentrationSlowed repolarizationOrthodromic stimulationPotassium equilibrium potentialCA1 regionPyramidal cellsRat hippocampusSynaptic activationBlocker tetraethylammoniumPostsynaptic activityRepetitive stimulationNeuronal activityNervous systemReceptors
1987
Modulation of neuronal activity in the hippocampus by 5-hydroxytryptamine and 5-hydroxytryptamine1a selective drugs
Peroutka S, Mauk M, Kocsis J. Modulation of neuronal activity in the hippocampus by 5-hydroxytryptamine and 5-hydroxytryptamine1a selective drugs. Neuropharmacology 1987, 26: 139-146. PMID: 2884586, DOI: 10.1016/0028-3908(87)90201-2.Peer-Reviewed Original ResearchConceptsTVX Q 7821Hippocampal slice preparationSlice preparationDose-dependent mannerMicromolar concentrationsApplication of drugsPopulation spikesRadioligand techniquesOH-DPATSchaffer collateralsHippocampal membranesNeuronal activityPyramidal layerKetanserinBaseline levelsBuspironeInitial increaseDPATSelective drugsDrugsField potentialsPhysiological effectsPopulationSimilar affinityBenzisothiazol-3