Multiple intravenous infusions versus a single infusion of mesenchymal stem cells in a rat model of cerebral ischemia.
Yokoyama T, Sasaki M, Nagahama H, Kataoka-Sasaki Y, Ukai R, Oka S, Kocsis J, Honmou O. Multiple intravenous infusions versus a single infusion of mesenchymal stem cells in a rat model of cerebral ischemia. Journal Of Neurosurgery 2024, 1-9. PMID: 39454218, DOI: 10.3171/2024.6.jns241111.Peer-Reviewed Original ResearchInfusion of mesenchymal stem cellsMiddle cerebral artery occlusionMiddle cerebral artery occlusion inductionMesenchymal stem cellsCorpus callosumSystemic infusion of mesenchymal stem cellsMultiple infusionsAcute phaseMesenchymal stem cell infusionCerebral ischemiaStem cellsMultiple intravenous infusionsRat model of cerebral ischemiaHigh-dose infusionPermanent middle cerebral artery occlusionIschemic lesion volumeModels of cerebral ischemiaCC thicknessRandomized clinical trialsCerebral artery occlusionNeural tractsAcute cerebral strokeFunctional recovery outcomesMRI diffusion tensor imagingMSC-3Intravenous Infusion of Autologous Mesenchymal Stem Cells Expanded in Auto Serum for Chronic Spinal Cord Injury Patients: A Case Series
Hirota R, Sasaki M, Iyama S, Kurihara K, Fukushi R, Obara H, Oshigiri T, Morita T, Nakazaki M, Namioka T, Namioka A, Onodera R, Kataoka-Sasaki Y, Oka S, Takemura M, Ukai R, Yokoyama T, Sasaki Y, Yamashita T, Kobayashi M, Okuma Y, Kondo R, Aichi R, Ohmatsu S, Kawashima N, Ito Y, Kobune M, Takada K, Ishiai S, Ogata T, Teramoto A, Yamashita T, Kocsis J, Honmou O. Intravenous Infusion of Autologous Mesenchymal Stem Cells Expanded in Auto Serum for Chronic Spinal Cord Injury Patients: A Case Series. Journal Of Clinical Medicine 2024, 13: 6072. PMID: 39458022, PMCID: PMC11509003, DOI: 10.3390/jcm13206072.Peer-Reviewed Original ResearchAmerican Spinal Injury Association Impairment ScaleSevere spinal cord injuryMesenchymal stem cell infusionAutologous mesenchymal stem cellsIntravenous infusionCase seriesMesenchymal stem cellsQuality of lifeAuto-serumSpinal cord injuryFunctional improvementChronic spinal cord injury patientsIntravenous infusion of mesenchymal stem cellsInfusion of mesenchymal stem cellsStem cellsCord injurySpinal Cord Independence Measure IIIAmerican Spinal Injury Association Impairment Scale grades CSpinal cord injury patientsChronic SCI patientsClassification of Spinal Cord InjuryNeurological Classification of Spinal Cord InjurySignificant functional improvementAssociation Impairment ScaleInternational Standards for Neurological Classification of Spinal Cord Injury