Cellular Protection Against Antibodies Occurs Through a Complement-Independent Pathway
Stowell S, Liepkalns J, Hendrickson J, Pierce K, Smith N, Zimring J. Cellular Protection Against Antibodies Occurs Through a Complement-Independent Pathway. Blood 2012, 120: 3290. DOI: 10.1182/blood.v120.21.3290.3290.Peer-Reviewed Original ResearchHOD RBCsKO miceSurface C3Nonimmunized miceAntigen levelsT cellsAntibody-reactive antigensC3 KO miceComplement inhibitory factorsAutoimmune hemolytic anemiaCell-mediated destructionAntibody-mediated destructionComplement-dependent mechanismAntibody-mediated processComplement-independent pathwaysComplement-independent mechanismsAntibody-secreting cellsNonimmunized control miceComplement degradation productsAntibody engagementCellular protectionCellular resistanceHOD antigenSubsequent transfusionsAntibody levels