Class switching is differentially regulated in RBC alloimmunization and vaccination
Prakash A, Medved J, Arneja A, Niebuhr C, Li A, Tarrah S, Boscia A, Burnett E, Singh A, Salazar J, Xu W, Santhanakrishnan M, Hendrickson J, Luckey C. Class switching is differentially regulated in RBC alloimmunization and vaccination. Transfusion 2023, 63: 826-838. PMID: 36907655, PMCID: PMC10851675, DOI: 10.1111/trf.17301.Peer-Reviewed Original ResearchConceptsSTAT6 KO miceSTAT6-deficient miceHOD RBCsRole of STAT6IgG subtypesRBC alloimmunizationKO miceDeficient miceTotal IgG responseIgG subclass distributionRBC transfusionIgG responsesWT miceAntibody responseIgG3 subclassSubclass distributionIgG subclassesMouse modelHuman patientsVaccinationMiceStudy designAltered levelsSubtypesClass switching