2014
Reticuloendothelial Saturation Dictates the Development of RBC Resistance to Antibody-Mediated Clearance Following Incompatible Transfusion
Arthur C, Mener A, Patel S, Rodrigues L, Xue C, Nickel R, Zimring J, Hendrickson J, Stowell S. Reticuloendothelial Saturation Dictates the Development of RBC Resistance to Antibody-Mediated Clearance Following Incompatible Transfusion. Blood 2014, 124: 1559. DOI: 10.1182/blood.v124.21.1559.1559.Peer-Reviewed Original ResearchIncompatible RBC transfusionRed blood cellsRBC transfusionInitial transfusionRBC clearanceAntigen modulationOld red blood cellsAntibody-mediated removalFlow cytometric analysisHOD antigenIncompatible transfusionsDetectable antigenRBC ageReticuloendothelial systemCytometric analysisPreferential clearanceAntibody-Mediated ClearanceRBC-specific antibodiesAntibody-opsonized cellsPhagocytic removalTransfused cellsC57BL/6 recipientsAntigen levelsFVB miceRecipient mice
2012
A Genetic Basis for Donor Variation in Generation of Prostaglandins and Leukotrienes in Stored RBCs Using a Mouse Model
Zimring J, Smith N, Stowell S, Francis R, Hod E, Hendrickson J, Dumont L, Roback J, Spitalnik S. A Genetic Basis for Donor Variation in Generation of Prostaglandins and Leukotrienes in Stored RBCs Using a Mouse Model. Blood 2012, 120: 844. DOI: 10.1182/blood.v120.21.844.844.Peer-Reviewed Original ResearchMouse modelRBC unitsArachidonic acidProstaglandin E2Eicosanoid generationRBC storageNegative clinical sequelaeSubstantial time-dependent increaseType of anemiaDonor variationGeneration of prostaglandinsOxidative damageTime-dependent increaseClinical sequelaeRBC transfusionEicosanoid levelsAdverse outcomesClear efficacyDonor miceFVB miceVascular pathologyPotent mediatorDay 0Alpha-tocopherolProduction of lactate