2015
Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization
Dubrac A, Genet G, Ola R, Zhang F, Pibouin-Fragner L, Han J, Zhang J, Thomas JL, Chedotal A, Schwartz MA, Eichmann A. Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization. Circulation 2015, 133: 409-421. PMID: 26659946, PMCID: PMC4729599, DOI: 10.1161/circulationaha.115.017537.Peer-Reviewed Original ResearchConceptsFront-rear polaritySprouting angiogenesisSignal integration mechanismImportant drug targetsNck adaptorsCytoskeletal dynamicsEndothelial cell migrationEmbryonic developmentAngiogenesis defectsPAK2 activationVessel sproutsNumber of diseasesBlood vessel growthDrug targetsCell migrationPostnatal retinaAngiogenic growthNckNck1AdaptorVessel growthKey processesEndothelial cellsPathological ocular neovascularizationInhibits neovascularizationVascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point
Baeyens N, Nicoli S, Coon BG, Ross TD, Van den Dries K, Han J, Lauridsen HM, Mejean CO, Eichmann A, Thomas JL, Humphrey JD, Schwartz MA. Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point. ELife 2015, 4: e04645. PMID: 25643397, PMCID: PMC4337723, DOI: 10.7554/elife.04645.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEndothelium, VascularHuman Umbilical Vein Endothelial CellsHumansMiceStress, PhysiologicalUmbilical VeinsVascular Endothelial Growth Factor Receptor-3Vascular RemodelingZebrafishConceptsEndothelial cells
2014
Tumor and Endothelial Cell Hybrids Participate in Glioblastoma Vasculature
Hallani S, Colin C, Houfi Y, Idbaih A, Boisselier B, Marie Y, Ravassard P, Labussière M, Mokhtari K, Thomas JL, Delattre JY, Eichmann A, Sanson M. Tumor and Endothelial Cell Hybrids Participate in Glioblastoma Vasculature. BioMed Research International 2014, 2014: 827327. PMID: 24868550, PMCID: PMC4017715, DOI: 10.1155/2014/827327.Peer-Reviewed Original ResearchAntigens, CDBrain NeoplasmsCadherinsCell DifferentiationCell ProliferationCoculture TechniquesEndoglinEndothelial CellsErbB ReceptorsGene Expression Regulation, NeoplasticGlioblastomaGreen Fluorescent ProteinsHuman Umbilical Vein Endothelial CellsHumansIn Situ Hybridization, FluorescenceLentivirusMicrocirculationNeoplasmsNeovascularization, PathologicPhenotypePlatelet Endothelial Cell Adhesion Molecule-1Receptors, Cell Surface