2020
Whole-Genome and RNA Sequencing Reveal Variation and Transcriptomic Coordination in the Developing Human Prefrontal Cortex
Werling DM, Pochareddy S, Choi J, An JY, Sheppard B, Peng M, Li Z, Dastmalchi C, Santpere G, Sousa AMM, Tebbenkamp ATN, Kaur N, Gulden FO, Breen MS, Liang L, Gilson MC, Zhao X, Dong S, Klei L, Cicek AE, Buxbaum JD, Adle-Biassette H, Thomas JL, Aldinger KA, O’Day D, Glass IA, Zaitlen NA, Talkowski ME, Roeder K, State MW, Devlin B, Sanders SJ, Sestan N. Whole-Genome and RNA Sequencing Reveal Variation and Transcriptomic Coordination in the Developing Human Prefrontal Cortex. Cell Reports 2020, 31: 107489. PMID: 32268104, PMCID: PMC7295160, DOI: 10.1016/j.celrep.2020.03.053.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceBrainComputational BiologyDatabases, GeneticExome SequencingGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyGenomicsHumansPhenotypePolymorphism, Single NucleotidePrefrontal CortexQuantitative Trait LociSequence Analysis, RNATranscriptomeWhole Genome SequencingConceptsExpression levelsGene expression levelsTranscriptomic coordinationDisorder lociNeuropsychiatric traitsSpecific genesRisk lociGene expressionGenomic variantsDevelopmental stagesCell typesGenesLociTissue RNACommon variantsPostnatal stagesUnique resourceSpecific variantsExpressionEQTLsVariantsGenomeHuman prefrontal cortexRNATraits
2015
A Dicer-miR-107 Interaction Regulates Biogenesis of Specific miRNAs Crucial for Neurogenesis
Ristori E, Lopez-Ramirez MA, Narayanan A, Hill-Teran G, Moro A, Calvo CF, Thomas JL, Nicoli S. A Dicer-miR-107 Interaction Regulates Biogenesis of Specific miRNAs Crucial for Neurogenesis. Developmental Cell 2015, 32: 546-560. PMID: 25662174, PMCID: PMC8950125, DOI: 10.1016/j.devcel.2014.12.013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCell DifferentiationCell ProliferationImmunoenzyme TechniquesIn Situ HybridizationMicroRNAsNeurogenesisNeuronsReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRhombencephalonRibonuclease IIIRNA, MessengerTumor Cells, CulturedZebrafishZebrafish ProteinsConceptsSpecific miRNAsDicer levelsBiogenesis of microRNAsNeuronal cellsDicer expression levelsExpression levelsDicer resultsMiRNA biogenesisMiR-107 functionsBiogenesisEctopic accumulationSubstrate selectivityPostmitotic neuronsMiR-107MiR-9MiRNAsHomeostatic levelsPrecise accumulationNeurogenesisDicerCellsAccumulationMicroRNAsRecent reportsProgenitors