2017
CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility
Chung JJ, Miki K, Kim D, Shim SH, Shi HF, Hwang JY, Cai X, Iseri Y, Zhuang X, Clapham DE. CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility. ELife 2017, 6: e23082. PMID: 28226241, PMCID: PMC5362262, DOI: 10.7554/elife.23082.Peer-Reviewed Original ResearchConceptsMammalian female reproductive tractSevere male subfertilityFemale reproductive tractIon channel complexNovel subunitCatSper complexEvolutionary adaptationMale subfertilityReproductive tractMouse spermSperm Ca2Normal fertilityTargeted disruptionSperm cellsFlagellaChannel complexFemale uterusSubunitsEpididymal spermatozoaSpermComplexesFertilizationSubfertilityUterusMice
2011
A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa
Chung JJ, Navarro B, Krapivinsky G, Krapivinsky L, Clapham DE. A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nature Communications 2011, 2: 153. PMID: 21224844, PMCID: PMC3999383, DOI: 10.1038/ncomms1153.Peer-Reviewed Original ResearchHyperactivation of motilityCatSper channel complexMale fertilityChannel α-subunitsNovel subunitNovel genesHyperactivated motilitySperm proteinsGene productsChannel assemblyAuxiliary subunitsΑ-subunitSuccessful fertilizationCalcium signalingSelective poresSpermatozoa lackChannel functionSubunitsSperm Ca2Channel complexCation channelsGenesChannel formationProteinAcrosome reaction