2018
Noradrenergic Activity in the Human Brain: A Mechanism Supporting the Defense Against Hypoglycemia
Belfort-DeAguiar R, Gallezot JD, Hwang JJ, Elshafie A, Yeckel CW, Chan O, Carson RE, Ding YS, Sherwin RS. Noradrenergic Activity in the Human Brain: A Mechanism Supporting the Defense Against Hypoglycemia. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 2244-2252. PMID: 29590401, PMCID: PMC6456998, DOI: 10.1210/jc.2017-02717.Peer-Reviewed Original ResearchConceptsHyperinsulinemic-hypoglycemic clampRaphe nucleusCounterregulatory hormonal responsesInsulin-treated patientsOptimal glycemic controlPositron emission tomographic imagingGlucose infusion rateBrain responsesLean healthy volunteersEmission tomographic imagingGlycemic controlNA outputGlucagon levelsPlasma epinephrineNoradrenergic activationNA responseNoradrenergic activityAutonomic outputIntravenous injectionHealthy volunteersInfusion rateHypoglycemiaMotor activityGrowth hormoneHormonal responses
2013
Decreased norepinephrine transporter availability in obesity: Positron Emission Tomography imaging with (S,S)-[11C]O-methylreboxetine
Li CS, Potenza MN, Lee DE, Planeta B, Gallezot JD, Labaree D, Henry S, Nabulsi N, Sinha R, Ding YS, Carson RE, Neumeister A. Decreased norepinephrine transporter availability in obesity: Positron Emission Tomography imaging with (S,S)-[11C]O-methylreboxetine. NeuroImage 2013, 86: 306-310. PMID: 24121204, PMCID: PMC3947246, DOI: 10.1016/j.neuroimage.2013.10.004.Peer-Reviewed Original ResearchConceptsBody mass indexMultilinear reference tissue model 2Norepinephrine transporterNoradrenergic dysfunctionObese individualsLean individualsStructural MR scansBPND valuesNorepinephrine transporter availabilityReference tissue model 2Positron emission tomography (PET) imagingEmission Tomography ImagingPositron emission tomographyBrain norepinephrine transportersNE clearanceMass indexRaphe nucleusLocus coeruleusSynaptic availabilityObese peopleTransporter availabilityOccipital cortexComparison subjectsHealthy individualsObesity