Localized transmeningeal muscimol prevents neocortical seizures in rats and nonhuman primates: Therapeutic implications
Ludvig N, Baptiste SL, Tang HM, Medveczky G, Von Gizycki H, Charchaflieh J, Devinsky O, Kuzniecky RI. Localized transmeningeal muscimol prevents neocortical seizures in rats and nonhuman primates: Therapeutic implications. Epilepsia 2009, 50: 678-693. PMID: 19055494, DOI: 10.1111/j.1528-1167.2008.01914.x.Peer-Reviewed Original ResearchConceptsMuscimol pretreatmentNeocortical seizuresEEG seizuresAdjacent EEG electrodesFocal neocortical seizuresEffects of AChIntractable focal epilepsySimilar deliveryBehavior of ratsSeizure activityFocal epilepsyAdditional ratsTherapeutic implicationsSubarachnoid spaceMuscimolSeizuresEEG power spectraParietal cortexRatsSquirrel monkeysAChElectroencephalography (EEG) activityMonkeysLast groupACSF