Metabolomic Analysis of Mice Exposed to Gamma Radiation Reveals a Systemic Understanding of Total-Body Exposure
Golla S, Golla JP, Krausz KW, Manna SK, Simillion C, Beyoğlu D, Idle JR, Gonzalez FJ. Metabolomic Analysis of Mice Exposed to Gamma Radiation Reveals a Systemic Understanding of Total-Body Exposure. Radiation Research 2017, 187: 612-629. PMID: 28467754, PMCID: PMC5539505, DOI: 10.1667/rr14592.1.Peer-Reviewed Original ResearchConceptsTotal body exposureRadiation exposureUltra-performance liquid chromatography-electrospray ionization-quadrupole timeBile acid metabolismChronic radiation toxicityMultiple radiation exposuresTissue-specific biomarkersMetabolomic analysisPotential novel approachGamma-irradiated groupsRadiation toxicityResponse markersBone marrowFunctional alterationsLiquid chromatography-electrospray ionization-quadrupole timeTriage protocolSpecific biomarkersDiagnostic markerMetabolic signaturesRadiosensitive tissuesMetabolic changesH postirradiationBiomarkersAcid metabolismTissue-level responses