2024
Open Burn Pit Exposure in Headache Disorder and Migraine
Sico J, Anthony S, Phadke M, Wang K, Skanderson M, Ney J, Seng E, Shapiro R, Sandbrink F, Scholten J, Graham G, Martini S, Fenton B. Open Burn Pit Exposure in Headache Disorder and Migraine. JAMA Network Open 2024, 7: e2431522. PMID: 39230902, PMCID: PMC11375476, DOI: 10.1001/jamanetworkopen.2024.31522.Peer-Reviewed Original ResearchConceptsBurn pit exposureVeterans Health Administration electronic health recordPit exposureHeadache disordersAdministration electronic health recordAnalytic sampleVeterans Health Administration facilitiesBurn pitsCohort studyVeterans Health AdministrationElectronic health recordsDose-dependent associationUS DepartmentHealth recordsRegistry participantsMilitary exposuresRetrospective cohort studyHealth AdministrationMain OutcomesHealth conditionsAdministration facilitiesRegistry questionnaireHighest quartilesIncident outcomesVeterans
2023
Longitudinal Care Patterns and Utilization Among Patients With New-Onset Neck Pain by Initial Provider Specialty
Fenton J, Fang S, Ray M, Kennedy J, Padilla K, Amundson R, Elton D, Haldeman S, Lisi A, Sico J, Wayne P, Romano P. Longitudinal Care Patterns and Utilization Among Patients With New-Onset Neck Pain by Initial Provider Specialty. Spine 2023, 48: 1409-1418. PMID: 37526092, DOI: 10.1097/brs.0000000000004781.Peer-Reviewed Original ResearchConceptsNeck painProvider specialtyTherapeutic interventionsCare patternsPain visitsInitial visitOptum Labs Data WarehouseDiagnostic imagingAcute back painAcute neck painPlurality of patientsRetrospective cohort studyElectronic health record dataLarge national cohortInvasive therapeutic interventionsHealth record dataCohort studyMajor surgeryBack painOutpatient visitsNational cohortPrimary careTherapeutic injectionsEmergency physiciansBACKGROUND DATACalcitonin Gene–Related Peptide Monoclonal Antibodies and Risk of SARS-CoV-2 Infection and Severe COVID-19 Outcomes Among Veterans With Migraine Disorder
Wang K, Fenton B, Deng Y, Anthony S, Dao V, Schindler E, Lipton R, Guirguis A, Skanderson M, Seng E, Sico J. Calcitonin Gene–Related Peptide Monoclonal Antibodies and Risk of SARS-CoV-2 Infection and Severe COVID-19 Outcomes Among Veterans With Migraine Disorder. JAMA Network Open 2023, 6: e2326371. PMID: 37523183, PMCID: PMC10391301, DOI: 10.1001/jamanetworkopen.2023.26371.Peer-Reviewed Original ResearchConceptsCalcitonin gene-related peptideSARS-CoV-2 infectionSevere COVID-19 outcomesCGRP mAbsMechanical ventilationSupplemental oxygenCOVID-19 outcomesSARS-CoV-2Cohort studyCGRP antagonistMAIN OUTCOMEMigraine disordersPositive SARS-CoV-2 test resultSARS-CoV-2 test resultsCOVID-19Protocol hazard ratiosRetrospective cohort studyMonoclonal antibody treatmentGene-related peptideLikelihood of hospitalizationCourse of diseasePeptide monoclonal antibodyElectronic health recordsNeuroimmune modulatorCumulative incidence
2022
Characteristics and Gender Differences of Headache in the Veterans Health Administration
Sico JJ, Seng E, Wang K, Skanderson M, Schindler E, Ney JP, Lorenze N, Kimber A, Lindsey H, Grinberg AS, Kuruvilla D, Higgins D, Graham G, Sandbrink F, Scholten J, Shapiro RE, Lipton RB, Fenton B. Characteristics and Gender Differences of Headache in the Veterans Health Administration. Neurology 2022, 99: e1993-e2005. PMID: 36100437, PMCID: PMC9651459, DOI: 10.1212/wnl.0000000000200905.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesFemaleHeadacheHumansMaleRetrospective StudiesSex FactorsUnited StatesUnited States Department of Veterans AffairsVeteransVeterans HealthConceptsVeterans Health AdministrationHeadache diagnosisHealthcare utilizationIncidence rateHeadache careHeadache typesHealth AdministrationSociodemographic characteristicsMilitary-related exposuresAge-adjusted incidenceEmergency department utilizationElectronic health record dataRetrospective cohort designType of headacheHigh incidence rateTraumatic brain injuryUnited States veteransHealth record dataPost-traumatic stress disorderGender differencesMilitary sexual traumaHeadache disordersBrain injuryHeadache specialistsCohort designRelationship Between Headache Characteristics and a Remote History of TBI in Veterans
Coffman C, Reyes D, Hess MC, Giakas AM, Thiam M, Sico JJ, Seng E, Renthal W, Rhoades C, Cai G, Androulakis XM. Relationship Between Headache Characteristics and a Remote History of TBI in Veterans. Neurology 2022, 99: e187-e198. PMID: 35470141, PMCID: PMC9280992, DOI: 10.1212/wnl.0000000000200518.Peer-Reviewed Original ResearchMeSH KeywordsBrain ConcussionBrain Injuries, TraumaticHeadacheHumansIraq War, 2003-2011Migraine DisordersRetrospective StudiesSeverity of Illness IndexVeteransConceptsMigraine-like featuresAlteration of consciousnessAdjusted odds ratioHeadache severityHeadache outcomesSevere headacheMild TBIPosttraumatic amnesiaTBI evaluationRetrospective chart reviewTraumatic brain injury severityComprehensive TBI evaluationBrain injury severityMental health diagnosesUnique risk factorsDose-response relationshipGreater headache severityRace/ethnicityNonblast injuriesChart reviewInjury characteristicsTBI severity groupsRemote historyRisk factorsSevere TBIBlood Pressure Trajectories and Outcomes for Veterans Presenting at VA Medical Centers with a Stroke or Transient Ischemic Attack
Arling G, Perkins A, Myers LJ, Sico JJ, Bravata DM. Blood Pressure Trajectories and Outcomes for Veterans Presenting at VA Medical Centers with a Stroke or Transient Ischemic Attack. The American Journal Of Medicine 2022, 135: 889-896.e1. PMID: 35292287, DOI: 10.1016/j.amjmed.2022.02.012.Peer-Reviewed Original ResearchMeSH KeywordsAntihypertensive AgentsBlood PressureHumansHypertensionIschemic Attack, TransientRetrospective StudiesStrokeVeteransConceptsSystolic blood pressure trajectoriesTransient ischemic attackSystolic blood pressureBlood pressure trajectoriesBlood pressureAntihypertensive medicationsIschemic attackPressure trajectoriesHigher systolic blood pressureLower systolic blood pressureCox proportional hazards modelBlood pressure reductionBlood pressure controlEmergency department visitsHazard of mortalityProportional hazards modelVA Medical CenterMedication intensificationCause mortalityVascular eventsIschemic strokeRetrospective cohortDepartment visitsHypertension managementIndex event
2021
Hospital Factors, Performance on Process Measures After Transient Ischemic Attack, and 90-Day Ischemic Stroke Incidence
Levine DA, Perkins AJ, Sico JJ, Myers LJ, Phipps MS, Zhang Y, Bravata DM. Hospital Factors, Performance on Process Measures After Transient Ischemic Attack, and 90-Day Ischemic Stroke Incidence. Stroke 2021, 52: 2371-2378. PMID: 34039034, PMCID: PMC8238890, DOI: 10.1161/strokeaha.120.031721.Peer-Reviewed Original ResearchConceptsIschemic stroke incidenceStroke incidenceHospital factorsPhysician staffingTIA patientsHypertension controlProcess measuresModerate potency statinTransient ischemic attackDays of dischargeEmergency department dischargeVeterans Affairs hospitalEligible patientsIschemic attackStatin useAntithrombotic useEmergency departmentEmergency physiciansInpatient unitDay 2HospitalPatient volumeFiscal year 2015PatientsIncidence
2019
Modelling care quality for patients after a transient ischaemic attack within the US Veterans Health Administration
Arling G, Sico JJ, Reeves MJ, Myers L, Baye F, Bravata DM. Modelling care quality for patients after a transient ischaemic attack within the US Veterans Health Administration. BMJ Open Quality 2019, 8: e000641. PMID: 31909209, PMCID: PMC6937041, DOI: 10.1136/bmjoq-2019-000641.Peer-Reviewed Original ResearchMeSH KeywordsAdministrative Claims, HealthcareAdultAgedAged, 80 and overEmergency Service, HospitalFemaleHumansIschemic Attack, TransientMaleMiddle AgedNeurologyPatient AdmissionQuality of Health CareReferral and ConsultationRetrospective StudiesStrokeTime FactorsUnited StatesUnited States Department of Veterans AffairsVeteransConceptsTransient ischemic attackCharlson Comorbidity IndexVeterans Health AdministrationHigher Charlson comorbidity indexUS Veterans Health AdministrationInpatient admissionsNeurological consultationNeurology consultationEmergency departmentIschemic attackPreventive careHealth AdministrationCare qualitySpeech deficitsHigher CCI scoresModerate potency statinRecurrent vascular eventsStroke center designationHistory of dementiaPreventive care qualityAntithrombotic medicationComorbidity indexCCI scoreED visitsRetrospective cohort
2012
Thrombocytopenia and In-hospital Mortality Risk among Ischemic Stroke Patients
Sico JJ, Phipps MS, Concato J, Wells CK, Lo AC, Nadeau SE, Williams LS, Peixoto AJ, Gorman M, Boice JL, Bravata DM. Thrombocytopenia and In-hospital Mortality Risk among Ischemic Stroke Patients. Journal Of Stroke And Cerebrovascular Diseases 2012, 22: e99-e102. PMID: 22974703, DOI: 10.1016/j.jstrokecerebrovasdis.2012.08.005.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBrain IschemiaFemaleHospital MortalityHumansMaleMiddle AgedRetrospective StudiesRiskSeverity of Illness IndexStrokeThrombocytopeniaConceptsAcute ischemic strokeIschemic stroke patientsHospital mortalityIschemic strokeStroke patientsHealth Stroke Scale scoreAcute ischemic stroke patientsStroke Scale scorePredictors of mortalityLogistic regression modelingAdmission thrombocytopeniaRetrospective cohortAntiplatelet effectUnadjusted analysesRisk factorsOdds ratioMortality riskThrombocytopeniaPatientsScale scoreHigh mortalityMortalityU.S. hospitalsStrokeNational Institute
2011
Anemia is Associated with Poor Outcomes in Patients with Less Severe Ischemic Stroke
Sico JJ, Concato J, Wells CK, Lo AC, Nadeau SE, Williams LS, Peixoto AJ, Gorman M, Boice JL, Bravata DM. Anemia is Associated with Poor Outcomes in Patients with Less Severe Ischemic Stroke. Journal Of Stroke And Cerebrovascular Diseases 2011, 22: 271-278. PMID: 22100828, DOI: 10.1016/j.jstrokecerebrovasdis.2011.09.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnemiaBrain IschemiaChi-Square DistributionDisability EvaluationFemaleHospice CareHospital MortalityHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioPatient AdmissionPatient DischargePredictive Value of TestsPrognosisRetrospective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexStrokeUnited StatesYoung AdultConceptsAcute ischemic strokeSevere ischemic strokeSevere strokeHospital mortalityIschemic strokeConsecutive ischemic stroke patientsHealth Stroke Scale scoreAdmission National InstitutesRole of anemiaStroke Scale scoreChronic kidney diseaseIschemic stroke patientsCongestive heart failureAcute myocardial infarctionAdmission anemiaCombined endpointRetrospective cohortStroke severitySymptom onsetHeart failureHospital admissionStroke patientsPoor outcomeKidney diseaseMyocardial infarction