2024
Open Burn Pit Exposure in Headache Disorder and Migraine
Sico J, Anthony S, Phadke M, Wang K, Skanderson M, Ney J, Seng E, Shapiro R, Sandbrink F, Scholten J, Graham G, Martini S, Fenton B. Open Burn Pit Exposure in Headache Disorder and Migraine. JAMA Network Open 2024, 7: e2431522. PMID: 39230902, PMCID: PMC11375476, DOI: 10.1001/jamanetworkopen.2024.31522.Peer-Reviewed Original ResearchConceptsBurn pit exposureVeterans Health Administration electronic health recordPit exposureHeadache disordersAdministration electronic health recordAnalytic sampleVeterans Health Administration facilitiesBurn pitsCohort studyVeterans Health AdministrationElectronic health recordsDose-dependent associationUS DepartmentHealth recordsRegistry participantsMilitary exposuresRetrospective cohort studyHealth AdministrationMain OutcomesHealth conditionsAdministration facilitiesRegistry questionnaireHighest quartilesIncident outcomesVeterans
2023
Changes in opioid prescribing in veterans with headache during the COVID‐19 pandemic: A regression discontinuity in time analysis
Wang K, Fenton B, Skanderson M, Black A, Becker W, Seng E, Anthony S, Guirguis A, Altalib H, Kimber A, Lorenze N, Scholten J, Graham G, Sandbrink F, Sico J. Changes in opioid prescribing in veterans with headache during the COVID‐19 pandemic: A regression discontinuity in time analysis. Headache The Journal Of Head And Face Pain 2023, 63: 1295-1303. PMID: 37596904, DOI: 10.1111/head.14605.Peer-Reviewed Original ResearchMorphine equivalent daily dosesVeterans Health AdministrationNumber of prescriptionsOpioid prescribingOpioid prescriptionsLong-term opioid therapyMME/dayRetrospective cohort studyEquivalent daily dosesCOVID-19 pandemicOpioid therapyPre-pandemic periodCohort studyDaily doseChronic painOutpatient visitsPrevious diagnosisDaily dosesMean ageSubgroup analysisHeadache disordersOpioid accessHealth AdministrationPrescribingCoronavirus diseaseLongitudinal Care Patterns and Utilization Among Patients With New-Onset Neck Pain by Initial Provider Specialty
Fenton J, Fang S, Ray M, Kennedy J, Padilla K, Amundson R, Elton D, Haldeman S, Lisi A, Sico J, Wayne P, Romano P. Longitudinal Care Patterns and Utilization Among Patients With New-Onset Neck Pain by Initial Provider Specialty. Spine 2023, 48: 1409-1418. PMID: 37526092, DOI: 10.1097/brs.0000000000004781.Peer-Reviewed Original ResearchConceptsNeck painProvider specialtyTherapeutic interventionsCare patternsPain visitsInitial visitOptum Labs Data WarehouseDiagnostic imagingAcute back painAcute neck painPlurality of patientsRetrospective cohort studyElectronic health record dataLarge national cohortInvasive therapeutic interventionsHealth record dataCohort studyMajor surgeryBack painOutpatient visitsNational cohortPrimary careTherapeutic injectionsEmergency physiciansBACKGROUND DATACalcitonin Gene–Related Peptide Monoclonal Antibodies and Risk of SARS-CoV-2 Infection and Severe COVID-19 Outcomes Among Veterans With Migraine Disorder
Wang K, Fenton B, Deng Y, Anthony S, Dao V, Schindler E, Lipton R, Guirguis A, Skanderson M, Seng E, Sico J. Calcitonin Gene–Related Peptide Monoclonal Antibodies and Risk of SARS-CoV-2 Infection and Severe COVID-19 Outcomes Among Veterans With Migraine Disorder. JAMA Network Open 2023, 6: e2326371. PMID: 37523183, PMCID: PMC10391301, DOI: 10.1001/jamanetworkopen.2023.26371.Peer-Reviewed Original ResearchConceptsCalcitonin gene-related peptideSARS-CoV-2 infectionSevere COVID-19 outcomesCGRP mAbsMechanical ventilationSupplemental oxygenCOVID-19 outcomesSARS-CoV-2Cohort studyCGRP antagonistMAIN OUTCOMEMigraine disordersPositive SARS-CoV-2 test resultSARS-CoV-2 test resultsCOVID-19Protocol hazard ratiosRetrospective cohort studyMonoclonal antibody treatmentGene-related peptideLikelihood of hospitalizationCourse of diseasePeptide monoclonal antibodyElectronic health recordsNeuroimmune modulatorCumulative incidence
2022
Military sexual trauma and incident hypertension: a 16-year cohort study of young and middle-aged men and women
Gaffey AE, Rosman L, Sico JJ, Haskell SG, Brandt CA, Bathulapalli H, Han L, Dziura J, Skanderson M, Burg MM. Military sexual trauma and incident hypertension: a 16-year cohort study of young and middle-aged men and women. Journal Of Hypertension 2022, 40: 2307-2315. PMID: 35983872, DOI: 10.1097/hjh.0000000000003267.Peer-Reviewed Original ResearchConceptsIncident hypertensionRisk factorsPsychiatric disordersMultivariate Cox proportional hazards modelVeterans Health Administration dataGreater riskCox proportional hazards modelTrauma-related psychiatric disordersMiddle-aged veteransCardiovascular risk factorsBaseline blood pressureElevated cardiovascular riskLarge prospective cohortHealth Administration dataMiddle-aged menProportional hazards modelSex-specific analysesPosttraumatic stress disorderMilitary sexual traumaCardiovascular riskCohort studyProspective cohortBlood pressureTreatment attenuatesCardiovascular impact
2021
LEFT ATRIAL STRAIN AND DIASTOLIC DYSFUNCTION AMONGST HIV-POSITIVE INDIVIDUALS: INSIGHTS FROM THE VETERANS AGING COHORT STUDY
Berg C, Patel B, Reynolds M, Tuzovic M, Chew K, Sico J, Bhattacharya D, Butt A, Lim J, Bedimo R, Brown S, Gottdiener J, Warner A, Freiberg M, So-Armah K, Nguyen K. LEFT ATRIAL STRAIN AND DIASTOLIC DYSFUNCTION AMONGST HIV-POSITIVE INDIVIDUALS: INSIGHTS FROM THE VETERANS AGING COHORT STUDY. Journal Of The American College Of Cardiology 2021, 77: 1422. DOI: 10.1016/s0735-1097(21)02780-7.Peer-Reviewed Original ResearchServices for Headache Disorder(s) among Men and Women Veterans across the Veterans Health Administration – a 10-year Cohort Study (4669)
Seng E, Fenton B, Wang K, Skanderson M, Sico J. Services for Headache Disorder(s) among Men and Women Veterans across the Veterans Health Administration – a 10-year Cohort Study (4669). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.4669.Peer-Reviewed Original Research
2020
Community‐Acquired Pneumonia and Risk of Cardiovascular Events in People Living With HIV
Zifodya JS, Duncan MS, So‐Armah K, Attia EF, Akgün KM, Rodriguez‐Barradas M, Marconi VC, Budoff MJ, Bedimo RJ, Alcorn CW, Hoo G, Butt AA, Kim JW, Sico JJ, Tindle HA, Huang L, Tate JP, Justice AC, Freiberg MS, Crothers K. Community‐Acquired Pneumonia and Risk of Cardiovascular Events in People Living With HIV. Journal Of The American Heart Association 2020, 9: e017645. PMID: 33222591, PMCID: PMC7763776, DOI: 10.1161/jaha.120.017645.Peer-Reviewed Original ResearchConceptsCommunity-acquired pneumoniaCVD risk factorsCVD eventsRisk factorsCAP severityHIV infectionHIV statusSevere community-acquired pneumoniaVeterans Aging Cohort StudyIncident CVD eventsCardiovascular disease eventsMultivariable-adjusted modelsAging Cohort StudyCox regression analysisDate of admissionMultivariable-adjusted analysesHigher mortality riskBackground HospitalizationCAP hospitalizationsHIV-uninfectedCardiovascular eventsIncident CVDCohort studyCVD riskUS veteransReason to doubt the ICHD-3 7-day inclusion criterion for mild TBI-related posttraumatic headache: A nested cohort study
McGeary DD, Resick PA, Penzien DB, Eapen BC, Jaramillo C, McGeary CA, Nabity PS, Peterson AL, Young-McCaughan S, Keane TM, Reed D, Moring J, Sico JJ, Pangarkar SS, Houle TT. Reason to doubt the ICHD-3 7-day inclusion criterion for mild TBI-related posttraumatic headache: A nested cohort study. Cephalalgia 2020, 40: 1155-1167. PMID: 32867535, DOI: 10.1177/0333102420953109.Peer-Reviewed Original ResearchConceptsMechanism of injuryHead injuryPre-existing migraineHeadache onsetProportion of veteransHeadache phenotypeCohort studyPosttraumatic headacheICHD-3 diagnostic criteriaMild traumatic injuryProportion of participantsSignificant differencesPercent of participantsPersistent headacheICHD-3Onset groupTraumatic injuryInclusion criteriaTreatment-seeking veteransPsychiatric symptomsMild TBIDiagnostic criteriaHeadacheSurvival analysisInjury
2019
Microvascular Disease, Peripheral Artery Disease and Amputation
Beckman JA, Duncan MS, Damrauer SM, Wells QS, Barnett JV, Wasserman DH, Bedimo RJ, Butt AA, Marconi VC, Sico JJ, Tindle HA, Bonaca MP, Aday AW, Freiberg MS. Microvascular Disease, Peripheral Artery Disease and Amputation. Circulation 2019, 140: 449-458. PMID: 31280589, PMCID: PMC6682431, DOI: 10.1161/circulationaha.119.040672.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAmputation, SurgicalComorbidityDiabetes ComplicationsDisease SusceptibilityExtremitiesFemaleFollow-Up StudiesHumansIschemiaKidney DiseasesMaleMicrocirculationMiddle AgedPeripheral Arterial DiseasePeripheral Nervous System DiseasesPrevalenceProcedures and Techniques UtilizationProportional Hazards ModelsProspective StudiesRetinal DiseasesRisk FactorsVeteransConceptsPeripheral artery diseaseRisk of amputationMicrovascular diseaseArtery diseaseRisk factorsVeterans Aging Cohort StudyCox proportional hazards regressionAdverse limb eventsPrevalent microvascular diseaseCardiovascular risk factorsTraditional risk factorsAging Cohort StudyMultivariable-adjusted analysesProportional hazards regressionLower limb amputationIncident amputationsPrior amputationCohort studyAmputation eventsHazards regressionLarge cohortElevated riskLimb amputationLimb eventsAmputationProcesses of Care Associated With Risk of Mortality and Recurrent Stroke Among Patients With Transient Ischemic Attack and Nonsevere Ischemic Stroke
Bravata DM, Myers LJ, Reeves M, Cheng EM, Baye F, Ofner S, Miech EJ, Damush T, Sico JJ, Zillich A, Phipps M, Williams LS, Chaturvedi S, Johanning J, Yu Z, Perkins AJ, Zhang Y, Arling G. Processes of Care Associated With Risk of Mortality and Recurrent Stroke Among Patients With Transient Ischemic Attack and Nonsevere Ischemic Stroke. JAMA Network Open 2019, 2: e196716. PMID: 31268543, PMCID: PMC6613337, DOI: 10.1001/jamanetworkopen.2019.6716.Peer-Reviewed Original ResearchMeSH KeywordsBrain IschemiaEligibility DeterminationFemaleHumansIschemic Attack, TransientLong Term Adverse EffectsMaleMiddle AgedMortalityOutcome and Process Assessment, Health CarePatient Care ManagementPrognosisRecurrenceRisk AssessmentRisk FactorsSeverity of Illness IndexStrokeUnited StatesVeterans Health ServicesConceptsTransient ischemic attackRecurrent ischemic strokeIschemic strokeRisk of deathRecurrent strokeProcess of careLower oddsMedication intensificationIschemic attackAtrial fibrillationVeterans Affairs emergency departmentAntihypertensive medication classesMortality 1 yearManagement of patientsMultivariable logistic regressionRisk of mortalityMultiple comparisonsCarotid artery imagingCause mortalityLipid managementMedication classesStatin medicationStatin therapyCohort studyStroke riskDepression and all‐cause mortality risk in HIV‐infected and HIV‐uninfected US veterans: a cohort study
So‐Armah K, Gupta S, Kundu S, Stewart J, Goulet J, Butt A, Sico J, Marconi, Crystal S, Rodriguez‐Barradas M, Budoff M, Gibert C, Chang C, Bedimo R, Freiberg. Depression and all‐cause mortality risk in HIV‐infected and HIV‐uninfected US veterans: a cohort study. HIV Medicine 2019, 20: 317-329. PMID: 30924577, PMCID: PMC6459698, DOI: 10.1111/hiv.12726.Peer-Reviewed Original ResearchConceptsHIV infectionMajor depressive disorderHIV statusDepressive symptomsMedian followCause mortalityDepressive disorderMortality riskVeterans Aging Cohort Study (VACS) dataDeath rateMajor depressive disorder diagnosisFirst clinic visitCause mortality riskPHQ-9 scoresNinth Revision codesPatient Health QuestionnaireDepressive disorder diagnosisPHQ-9 dataCohort study dataContribution of depressionDepression definitionsClinic visitsCohort studyComorbid conditionsEligible participants
2018
Receipt of cardiac screening does not influence 1-year post–cerebrovascular event mortality
Sico JJ, Baye F, Myers LJ, Concato J, Ferguson J, Cheng EM, Jadbabaie F, Yu Z, Arling G, Zillich AJ, Reeves MJ, Williams LS, Bravata DM. Receipt of cardiac screening does not influence 1-year post–cerebrovascular event mortality. Neurology Clinical Practice 2018, 8: 192-200. PMID: 30105158, PMCID: PMC6075977, DOI: 10.1212/cpj.0000000000000465.Peer-Reviewed Original ResearchCardiac stress testingCoronary heart diseaseStroke/TIACardiac screeningCerebrovascular diseaseStress testingOccult coronary heart diseaseIschemic stroke/TIAChest pain historyCommon Procedural Terminology codesVA emergency departmentIntermediate-risk patientsCardiac risk scoreDays of dischargeHigh-risk patientsObservational cohort studyAcute care facilitiesExpert consensus guidelinesRoutine clinical practiceProcedural Terminology codesEligible patientsCerebrovascular eventsCohort studyPain historyConsensus guidelinesAssociation of neurologist care with headache expenditures: A population-based, longitudinal analysis
Ney JP, Sico JJ, Klein BC, Magliocco B, Callaghan BC, Esper G. Association of neurologist care with headache expenditures: A population-based, longitudinal analysis. Cephalalgia 2018, 38: 1876-1884. PMID: 29504480, DOI: 10.1177/0333102418762572.Peer-Reviewed Original ResearchConceptsNeurologist careAmbulatory care visitsLongitudinal cohort studyMedical Expenditure Panel SurveyResults Eight hundredHealth care costsMean annual expenditureCare visitsCohort studyHealthcare utilizationClinical variablesDiagnostic codesAdjusted associationsCare costsHeadache sufferersHealthcare expendituresYear oneCareHeadacheSignificant reductionAdult respondentsLongitudinal analysisAssociationYear twoAnnual expenditurePost‐stroke hypertension control and receipt of health care services among veterans
Kohok DD, Sico JJ, Baye F, Myers L, Coffing J, Kamalesh M, Bravata DM. Post‐stroke hypertension control and receipt of health care services among veterans. Journal Of Clinical Hypertension 2018, 20: 382-387. PMID: 29397583, PMCID: PMC8031130, DOI: 10.1111/jch.13194.Peer-Reviewed Original ResearchConceptsPrimary careHypertension managementRecurrent stroke rateGoal blood pressureRetrospective cohort studyAcute ischemic strokeIschemic stroke patientsIschemic stroke admissionsFuture intervention studiesHealth care servicesBP controlBP trajectoriesPC visitsGoal BPHypertension controlStroke admissionsCohort studyIschemic strokeBlood pressureMean BPHealthcare utilizationMedian timeStroke patientsStroke ratePatients
2014
HIV Infection and Cardiovascular Disease in Women
Womack JA, Chang C, So‐Armah K, Alcorn C, Baker JV, Brown ST, Budoff M, Butt AA, Gibert C, Goetz MB, Gottdiener J, Gottlieb S, Justice AC, Leaf D, McGinnis K, Rimland D, Rodriguez‐Barradas M, Sico J, Skanderson M, Tindle H, Tracy RP, Warner A, Freiberg MS. HIV Infection and Cardiovascular Disease in Women. Journal Of The American Heart Association 2014, 3: e001035. PMID: 25324353, PMCID: PMC4323817, DOI: 10.1161/jaha.114.001035.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionAgedCardiovascular DiseasesCase-Control StudiesComorbidityConfidence IntervalsFemaleHIV InfectionsHumansLongitudinal StudiesMiddle AgedPrevalenceProportional Hazards ModelsProspective StudiesRisk AssessmentSeverity of Illness IndexSurvival AnalysisUnited StatesUser-Computer InterfaceVeteransConceptsRisk of CVDCVD eventsCardiovascular diseaseHIV infectionVeterans Aging Cohort StudyCox proportional hazards modelHIV uninfected womenIncident CVD eventsIncident cardiovascular diseaseIndependent risk factorAging Cohort StudyClinical Modification codesFirst clinical encounterDeath certificate dataProportional hazards modelSubstance use/abuseUse/abuseRace/ethnicityUninfected womenHepatitis CHIV- womenLast followCohort studyIschemic strokeUnstable angina
2011
Validating Smoking Data From the Veteran’s Affairs Health Factors Dataset, an Electronic Data Source
McGinnis KA, Brandt CA, Skanderson M, Justice AC, Shahrir S, Butt AA, Brown ST, Freiberg MS, Gibert CL, Goetz MB, Kim JW, Pisani MA, Rimland D, Rodriguez-Barradas MC, Sico JJ, Tindle HA, Crothers K. Validating Smoking Data From the Veteran’s Affairs Health Factors Dataset, an Electronic Data Source. Nicotine & Tobacco Research 2011, 13: 1233-1239. PMID: 21911825, PMCID: PMC3223583, DOI: 10.1093/ntr/ntr206.Peer-Reviewed Original ResearchConceptsSmoking statusHealth factorsSmoking dataKappa statisticsSmoking variablesVeterans Aging Cohort StudyAging Cohort StudySelf-reported smoking dataCohort studyCurrent smokersSmoking interventionsVirtual cohortElectronic data sourcesEMR dataFuture studiesStatusParticipantsFactorsHIVSmokersSmokingStudy surveyCohort