Clinical factors associated with acute exacerbations of chronic rhinosinusitis
Kwah JH, Somani SN, Stevens WW, Kern RC, Smith SS, Welch KC, Conley DB, Tan BK, Grammer LC, Yang A, Schleimer RP, Peters AT. Clinical factors associated with acute exacerbations of chronic rhinosinusitis. Journal Of Allergy And Clinical Immunology 2020, 145: 1598-1605. PMID: 32004523, PMCID: PMC8177481, DOI: 10.1016/j.jaci.2020.01.023.Peer-Reviewed Original ResearchConceptsFrequent acute exacerbationsChronic rhinosinusitisAcute exacerbationAllergic rhinitisClinical factorsEosinophil countAutoimmune diseasesSignificant health care burdenSinus disease severityRetrospective cohort studySystemic corticosteroid useHealth care burdenHigh-risk phenotypeAntibiotic allergyExacerbation frequencyFrequent exacerbationsSinus symptomsCorticosteroid useCohort studyLower FEVNasal polyposisAntibody deficiencyImpaired qualityImmunologic diseasesOdds ratio