2016
The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect
Montalvo-Ortiz JL, Bordner KA, Carlyle BC, Gelernter J, Simen AA, Kaufman J. The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect. Behavioural Brain Research 2016, 315: 71-74. PMID: 27506655, PMCID: PMC5396458, DOI: 10.1016/j.bbr.2016.08.010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDepressionDisease Models, AnimalGene Expression RegulationInhibitor of Differentiation ProteinsMaleMaternal DeprivationMaze LearningMiceMice, Inbred C57BLMice, Inbred DBAMicroarray AnalysisNerve Tissue ProteinsNeuronal PlasticityPrefrontal CortexReceptors, N-Methyl-D-AspartateRNA, MessengerStress, PsychologicalSwimmingConceptsTubulin Polymerization Promoting ProteinRole of genesGene expression dataEpigenetic changesGene expressionPhenotype dataExpression dataPrefrontal cortex tissueGenesSecondary analysisMedial prefrontal cortex (mPFC) tissueGlutamate NMDA receptorsAdult male miceId-3Early life stressPhenotypeSwimming testMale miceNMDA receptorsDepression riskMaternal separationMouse modelDepressive phenotypeBrain circuitryBehavioral differences
2012
Corticotrophin Releasing Factor Accelerates Neuropathology and Cognitive Decline in a Mouse Model of Alzheimer's Disease
Dong H, Murphy KM, Meng L, Montalvo-Ortiz J, Zeng Z, Kolber BJ, Zhang S, Muglia LJ, Csernansky JG. Corticotrophin Releasing Factor Accelerates Neuropathology and Cognitive Decline in a Mouse Model of Alzheimer's Disease. Journal Of Alzheimer's Disease 2012, 28: 579-592. PMID: 22045495, PMCID: PMC3494090, DOI: 10.3233/jad-2011-111328.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAlzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnalysis of VarianceAnimalsAnxietyBody WeightCalcium-Calmodulin-Dependent Protein Kinase Type 2Cognition DisordersConditioning, PsychologicalCorticosteroneCorticotropin-Releasing HormoneDark AdaptationDendritic SpinesDisease Models, AnimalDoxycyclineEnzyme-Linked Immunosorbent AssayExploratory BehaviorFearGene Expression RegulationHumansMiceMice, TransgenicNeuronsPlaque, AmyloidProsencephalonReceptors, Corticotropin-Releasing HormoneSilver StainingTubulinConceptsCorticotrophin-releasing factorTransgenic mouse modelTriple transgenic mouse modelTT miceMouse modelMonths of ageAlzheimer's diseaseExpression of CRFChronic stressHuman amyloid-β protein precursorNovel transgenic mouse modelDendritic spine densityAmyloid-β protein precursorAnxiety-like behaviorAβPP genePyramidal neuronsSpine densityAmyloid depositionAmyloid metabolismCRF expressionFrontal cortexBehavioral deficitsDendritic branchingCognitive declineMice