2022
Psychosocial Factors Associated With Accelerated GrimAge in Male U.S. Military Veterans
Tamman AJF, Nagamatsu S, Krystal JH, Gelernter J, Montalvo-Ortiz JL, Pietrzak RH. Psychosocial Factors Associated With Accelerated GrimAge in Male U.S. Military Veterans. American Journal Of Geriatric Psychiatry 2022, 31: 97-109. PMID: 36210262, DOI: 10.1016/j.jagp.2022.09.002.Peer-Reviewed Original ResearchConceptsRisk factorsPremature mortalityU.S. veteransPsychosocial variablesNovel epigenetic clockLifetime substance use disorderRisk stratification modelMale U.S. veteransCross-sectional studyU.S. veteran populationWeekly physical exerciseSubstance use disordersMale U.S. military veteransBiological agingU.S. military veteransHealth morbidityModifiable correlatesMortality riskSleep qualityHigh riskGreater oddsUse disordersPhysical exercisePsychosocial factorsVeteran population
2019
Accelerated DNA Methylation Aging in U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study
Tamman AJF, Montalvo-Ortiz JL, Southwick SM, Krystal JH, Levy BR, Pietrzak RH. Accelerated DNA Methylation Aging in U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study. American Journal Of Geriatric Psychiatry 2019, 27: 528-532. PMID: 30792041, DOI: 10.1016/j.jagp.2019.01.001.Peer-Reviewed Original ResearchConceptsNational HealthPsychosocial factorsVeterans StudyMale U.S. veteransLifetime trauma burdenAccelerated DNA methylation agingDNA methylation agingU.S. military veteransMethylation agingTrauma burdenU.S. veteransPrevention effortsAdditional correlatesNegative beliefsMilitary veteransSexual traumaVeteransTraumatic stressDNA methylationHealthChild sexual traumaBody massRepresentative sample
2017
Histone deacetylase inhibitors reverse age-related increases in side effects of haloperidol in mice
Montalvo-Ortiz JL, Fisher DW, Rodríguez G, Fang D, Csernansky JG, Dong H. Histone deacetylase inhibitors reverse age-related increases in side effects of haloperidol in mice. Psychopharmacology 2017, 234: 2385-2398. PMID: 28421257, PMCID: PMC5538925, DOI: 10.1007/s00213-017-4629-2.Peer-Reviewed Original ResearchConceptsMotor side effectsAged miceSide effectsValproic acidAge-related increaseHDAC inhibitorsAntipsychotic-induced side effectsDrd2 promoterAdjunct treatment strategyHistone deacetylase inhibitor valproic acidProtein levelsDopamine D2 receptorsInhibitor valproic acidHistone deacetylase inhibitorsDrug-dependent decreaseBackgroundOlder patientsMotor deficitsC57BL/6 miceAntagonist haloperidolTreatment strategiesYoung miceD2 receptorsPharmacodynamic mechanismsHaloperidolDeacetylase inhibitors
2013
HDAC Inhibitors Restore the Capacity of Aged Mice to Respond to Haloperidol through Modulation of Histone Acetylation
Montalvo-Ortiz JL, Keegan J, Gallardo C, Gerst N, Tetsuka K, Tucker C, Matsumoto M, Fang D, Csernansky JG, Dong H. HDAC Inhibitors Restore the Capacity of Aged Mice to Respond to Haloperidol through Modulation of Histone Acetylation. Neuropsychopharmacology 2013, 39: 1469-1478. PMID: 24366052, PMCID: PMC3988551, DOI: 10.1038/npp.2013.346.Peer-Reviewed Original ResearchConceptsC-fos expressionAged miceValproic acidNucleus accumbensPrefrontal cortexYoung miceMS-275HDAC inhibitorsC-Fos expression patternHDAC inhibitor valproic acidAntipsychotic drug actionEffects of haloperidolAge-related decreaseInhibitor valproic acidHistone deacetylase inhibitorsElderly patientsHAL administrationHistone acetylationAntipsychotic drugsAvoidance responseBehavioral disturbancesElderly individualsClinical experienceHaloperidolEpigenetic changes