2018
Methylation in OTX2 and related genes, maltreatment, and depression in children
Kaufman J, Wymbs NF, Montalvo-Ortiz JL, Orr C, Albaugh MD, Althoff R, O’Loughlin K, Holbrook H, Garavan H, Kearney C, Yang BZ, Zhao H, Peña C, Nestler EJ, Lee RS, Mostofsky S, Gelernter J, Hudziak J. Methylation in OTX2 and related genes, maltreatment, and depression in children. Neuropsychopharmacology 2018, 43: 2204-2211. PMID: 30089883, PMCID: PMC6135753, DOI: 10.1038/s41386-018-0157-y.Peer-Reviewed Original ResearchConceptsMouse modelStress-related depressive disordersResting-state functional connectivity dataResting-state functional MRI dataDepressive-like behaviorEarly life stressSubset of childrenDNA specimensMedial frontal cortexPeripheral markersMeasures of depressionHomeobox 2 geneSubcallosal gyrusFunctional connectivity dataDepressive disorderFrontal cortexChild adversityMultiple molecular toolsFunctional MRI dataFrontal poleLarger studyFunctional connectivitySaliva samplesBilateral regionsUnbiased transcriptomics
2008
Chronic underactivity of medial frontal cortical β2-containing nicotinic receptors increases clozapine-induced working memory impairment in female rats
Levin ED, Perkins A, Brotherton T, Qazi M, Berez C, Montalvo-Ortiz J, Davis K, Williams P, Christopher NC. Chronic underactivity of medial frontal cortical β2-containing nicotinic receptors increases clozapine-induced working memory impairment in female rats. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2008, 33: 296-302. PMID: 19146909, PMCID: PMC2684503, DOI: 10.1016/j.pnpbp.2008.12.003.Peer-Reviewed Original ResearchMeSH KeywordsAconitineAlpha7 Nicotinic Acetylcholine ReceptorAnimalsAntipsychotic AgentsCerebral CortexChronic DiseaseClozapineDihydro-beta-ErythroidineFemaleMaze LearningMemory DisordersMemory, Short-TermMicroinjectionsNicotinic AntagonistsPrefrontal CortexRatsRats, Sprague-DawleyReceptors, NicotinicConceptsMedial frontal cortexMemory impairmentNicotinic receptor activityFrontal cortexCognitive functionHippocampal infusionsRadial arm mazeNicotinic receptor involvementNicotinic receptor lossProcognitive treatmentsBrain systemsCognitive effectsMemory functionAntipsychotic drug interactionsMLA infusionsMemoryNicotinic receptorsCognitive impairmentBrain functionFemale ratsAntipsychotic drugsReceptor lossAntispychotic drugsCurrent studyAlzheimer's disease