2022
Central and Peripheral Immune Dysregulation in Posttraumatic Stress Disorder: Convergent Multi-Omics Evidence
Núñez-Rios DL, Martínez-Magaña JJ, Nagamatsu ST, Andrade-Brito DE, Forero DA, Orozco-Castaño CA, Montalvo-Ortiz JL. Central and Peripheral Immune Dysregulation in Posttraumatic Stress Disorder: Convergent Multi-Omics Evidence. Biomedicines 2022, 10: 1107. PMID: 35625844, PMCID: PMC9138536, DOI: 10.3390/biomedicines10051107.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPosttraumatic stress disorderPeripheral immune systemImmune systemInflammatory systemTrauma exposureStress disorderPeripheral immune dysregulationToll-like receptorsLifetime trauma exposurePotential novel drug targetsEtiology of PTSDImmune dysregulationInflammatory dysregulationHPA axisNovel drug targetsImmunological responseInflammatory signalingGeneral populationAnimal modelsIntegrative multi-omics approachPTSD treatmentMultifactorial disorderBrain tissueHallmark featureDysregulation
2018
Corticotrophin releasing factor receptor 1 antagonists prevent chronic stress-induced behavioral changes and synapse loss in aged rats
Dong H, Keegan JM, Hong E, Gallardo C, Montalvo-Ortiz J, Wang B, Rice KC, Csernansky J. Corticotrophin releasing factor receptor 1 antagonists prevent chronic stress-induced behavioral changes and synapse loss in aged rats. Psychoneuroendocrinology 2018, 90: 92-101. PMID: 29477954, PMCID: PMC5864558, DOI: 10.1016/j.psyneuen.2018.02.013.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsAnxietyBehaviorBehavior, AnimalCorticotropin-Releasing HormoneDepressionDisease Models, AnimalFemaleHypothalamo-Hypophyseal SystemMalePituitary-Adrenal SystemPyrimidinesPyrrolesRatsRats, Sprague-DawleyReceptors, Corticotropin-Releasing HormoneStress, PsychologicalSynapsesConceptsStress-induced behavioral changesStress-induced anxietyAnxiety-related behaviorMemory deficitsChronic stressSynapse lossCRF1 antagonistsFactor receptor 1 antagonistCortical dendritic spinesHPA axis dysfunctionBody weight lossReceptor 1 antagonistMonths of ageSubset of animalsBehavioral changesFactor receptor 1Axis dysfunctionAged brainAged ratsPotential therapyDendritic spinesAnimal modelsCorticosterone levelsAlzheimer's diseaseReceptor 1