2021
The Role of 5-HT2B Receptor on Aggression and Drugs of Abuse
Montalvo-Ortiz J, Coccaro E. The Role of 5-HT2B Receptor on Aggression and Drugs of Abuse. The Receptors 2021, 35: 291-307. DOI: 10.1007/978-3-030-55920-5_17.ChaptersAggressive behaviorDrugs of abuseReceptor subtypesBrain regionsDifferent subtypesNormal levelsDrug abuseInhibitory effectSubstance useInfluence of substancesGenetic factorsReceptor familyReceptorsSubtypesGenetic variantsImpulsive behaviorHigher proportionAbuseViolent behaviorMonoaminesEnvironmental factorsBrainCocaineContext of aggression
2018
Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response
Montalvo-Ortiz JL, Zhou H, D’Andrea I, Maroteaux L, Lori A, Smith A, Ressler KJ, Nuñez YZ, Farrer LA, Zhao H, Kranzler HR, Gelernter J. Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response. Molecular Psychiatry 2018, 23: 2277-2286. PMID: 29875475, PMCID: PMC6281782, DOI: 10.1038/s41380-018-0077-6.Peer-Reviewed Original ResearchConceptsGrady Trauma ProjectAfrican AmericansWild-type miceReceptor geneEffects of cannabisWide significant risk lociResident-intruder paradigmImpulsivity/aggressionConcordant findingsTHC administrationKnockout miceTranslational studiesAA subjectsCannabis useStudy designTrauma ProjectAdverse effectsMiceCannabisAggressive behaviorEuropean AmericansNominal associationAdverse consequencesGenome-wide association study (GWAS) designRisk loci