Janice Jin Hwang, MD
Assistant Professor AdjunctCards
Appointments
Contact Info
About
Titles
Assistant Professor Adjunct
Biography
Dr. Hwang is an endocrinologist and Assistant Professor in the Division of Endocrinology at the Yale School of Medicine. She graduated magna cum laude from Princeton University in 2001 with a major in molecular biology followed by Harvard Medical School in 2006. She completed her residency training in Internal Medicine at the Beth Israel Deaconess Medical Center in Boston, MA and also served as a Chief Medical Resident. Dr. Hwang received her fellowship training in Endocrinology and Metabolism at Massachusetts General Hospital and moved to Yale in 2012 to continue her research training with Dr. Robert Sherwin. Her academic interests are at the intersection of metabolism, neuroscience and imaging. Her research focuses on using advanced brain imaging modalities such as functional MRI and magnetic resonance spectroscopy coupled with classic investigative techniques in metabolism to understand the effects of diabetes and obesity on the brain. Her research has been supported by the National Institutes of Health, the Yale Diabetes Research Center, the Endocrine Fellows Foundation, and the American Diabetes Association. She is the recipient of several awards for her research including the Marilyn Fishman Award for Diabetes Research, the Metabolism Junior Investigator award as well as a Yale Center for Clinical Investigation Junior Faculty Scholars Award.
Appointments
Endocrinology
Assistant Professor AdjunctPrimary
Other Departments & Organizations
- Diabetes Research Center
- Endocrinology
- Hwang Lab
- Internal Medicine
- Obesity Research Working Group
Education & Training
- MHS
- Yale University (2017)
- Research Fellow
- Yale School of Medicine (2014)
- Clinical and Research Fellow
- Massachusetts General Hospital (2012)
- Chief Medical Resident
- Beth Israel Deaconess Medical Center (2011)
- Residency
- Beth Israel Deaconess Medical Center (2009)
- MD
- Harvard Medical School (2006)
- AB
- Princeton University, Molecular Biology (2001)
Research
Overview
Medical Subject Headings (MeSH)
ORCID
0000-0002-8395-5659
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Elizabeth Sanchez Rangel, MD
Lisa Parikh, MD
Graeme Mason, PhD
Ania Jastreboff, MD, PhD
Anika K. Anam, MD
Babar Khokhar, MD, MBA, FAAN (Neurology)
Obesity
Diabetes Mellitus, Type 2
Diabetes Mellitus, Type 1
Publications
2024
Low‐calorie diet‐induced weight loss is associated with altered brain connectivity and food desire in obesity
Hoang H, Lacadie C, Hwang J, Lam K, Elshafie A, Rosenberg S, Watt C, Sinha R, Constable R, Savoye M, Seo D, Belfort‐DeAguiar R. Low‐calorie diet‐induced weight loss is associated with altered brain connectivity and food desire in obesity. Obesity 2024, 32: 1362-1372. PMID: 38831482, PMCID: PMC11211061, DOI: 10.1002/oby.24046.Peer-Reviewed Original ResearchAltmetricConceptsFunctional magnetic resonance imagingIntrinsic connectivity distributionDiet-induced weight lossBrain connectivityAssociated with altered brain connectivityLow-calorie dietEating behavior changesShort-term low-calorie dietRight hippocampusTemporal cortexBrain networksWeight lossBrain clustersEffects of diet-induced weight lossGroup differencesFood desireGlucose levelsDiagnosis of type 2 diabetesBehavioral changesMagnetic resonance imagingType 2 diabetesBrainLeptin levelsFood intakeResonance imagingDeficits in brain glucose transport among younger adults with obesity
Gunawan F, Matson B, Coppoli A, Jiang L, Ding Y, Perry R, Sanchez‐Rangel E, DeAguiar R, Behar K, Rothman D, Mason G, Hwang J. Deficits in brain glucose transport among younger adults with obesity. Obesity 2024, 32: 1329-1338. PMID: 38764181, DOI: 10.1002/oby.24034.Peer-Reviewed Original ResearchAltmetricConceptsBrain glucose transportLean participantsMarkers of insulin resistanceMagnetic resonance spectroscopy scansEffect of obesityAssociated with alterationsLong-term brain functionCerebral glucose metabolic rateGlucose transportGlucose metabolic rateCardiometabolic comorbiditiesBrain energy utilizationPeripheral markersHyperglycemic clampInsulin resistanceObesityBrain glucose uptakeHuman findingsEating behaviorsYounger ageYoung healthy participantsNeurocognitive functionGlucose transport capacityBrain functionNonesterified fatty acids
2022
Pathophysiology and management of hypoglycemia in diabetes
Sanchez‐Rangel E, Deajon‐Jackson J, Hwang JJ. Pathophysiology and management of hypoglycemia in diabetes. Annals Of The New York Academy Of Sciences 2022, 1518: 25-46. PMID: 36202764, DOI: 10.1111/nyas.14904.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsType 1 diabetes mellitusCounter-regulatory hormonal responsesMechanism of hypoglycemiaDuration of diabetesManageable chronic diseaseOptimal glycemic controlManagement of hypoglycemiaTreatment of hypoglycemiaNew insulin formulationsDiscovery of insulinGlycemic controlDiabetes mellitusTherapeutic optionsBrain glucoseChronic diseasesNovel therapiesDiabetes managementHypoglycemiaPharmacologic targetHormonal responsesInsulin formulationsDiabetesPatientsCurrent literatureDelivery devicesStress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating
Bini J, Parikh L, Lacadie C, Hwang JJ, Shah S, Rosenberg SB, Seo D, Lam K, Hamza M, De Aguiar RB, Constable T, Sherwin RS, Sinha R, Jastreboff AM. Stress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating. NeuroImage Clinical 2022, 36: 103202. PMID: 36126514, PMCID: PMC9486604, DOI: 10.1016/j.nicl.2022.103202.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCerebral blood flowRegional cerebral blood flowBlood flowMetabolic hormonesRandomized double-blind cross-over designDouble-blind cross-over designStress level glucocorticoidsPrimary sensory cortexPerfusion magnetic resonanceCross-over designMedial temporal gyrusWhole-brain voxelMedial brainstemSaline daysOvernight infusionCBF responseHunger ratingsPlasma insulinGlucocorticoid effectsHedonic signalsObesity riskLimbic regionsFood intakeNeural regulationDistinct brain networksInsulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity
Anam AK, Cooke KM, Dratver MB, O'Bryan JV, Perley LE, Guller SM, Hwang JJ, Taylor HS, Goedeke L, Kliman HJ, Vatner DF, Flannery CA. Insulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity. Molecular Metabolism 2022, 64: 101574. PMID: 35970449, PMCID: PMC9440306, DOI: 10.1016/j.molmet.2022.101574.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDe novo lipogenesisFetal adiposityFatty acid uptakeMaternal obesityObese womenNormal weightExcess adiposityVillous explantsInsulin receptorNewborns of mothersNormal-weight womenAcid uptakePlacental villous explantsTranscription factor SREBP-1Insulin-like growth factor 2Effect of insulinFatty acid oxidationPlacental triglyceridesPlacental responsesElevated triglyceridesMaternal hyperglycemiaWeight womenGrowth factor 2Diabetes riskPlacental metabolismReversibility of brain glucose kinetics in type 2 diabetes mellitus
Sanchez-Rangel E, Gunawan F, Jiang L, Savoye M, Dai F, Coppoli A, Rothman DL, Mason GF, Hwang JJ. Reversibility of brain glucose kinetics in type 2 diabetes mellitus. Diabetologia 2022, 65: 895-905. PMID: 35247067, PMCID: PMC8960594, DOI: 10.1007/s00125-022-05664-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsType 2 diabetesBrain glucose levelsGlucose levelsHyperglycaemic clampGlycaemic controlBrain glucoseUncontrolled type 2 diabetesType 2 diabetes mellitusConclusions/interpretationThese findingsAims/hypothesisWePlasma glucose levelsLinear mixed-effects regression modelsMixed-effects regression modelsContinuous glucose monitoringMinimal weight changeMagnitude of improvementAge 44.8MethodsEight individualsSD HbA1cDiabetes mellitusCerebral glucoseInterpretationThese findingsWeek interventionRegimen intensificationPost intervention
2021
Food for Thought
Hwang JJ. Food for Thought. Journal Of Nutrition 2021, 151: 2089-2091. PMID: 34195820, DOI: 10.1093/jn/nxab210.Peer-Reviewed Original ResearchAltmetric
2020
Glycemic Variability and CNS Inflammation: Reviewing the Connection
Watt C, Sanchez-Rangel E, Hwang JJ. Glycemic Variability and CNS Inflammation: Reviewing the Connection. Nutrients 2020, 12: 3906. PMID: 33371247, PMCID: PMC7766608, DOI: 10.3390/nu12123906.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBlood-brain barrierGlycemic variabilityOxidative stressCentral nervous system outcomesImpact of hyperglycemiaType 2 diabetesCNS inflammationVascular complicationsVascular inflammationCognitive dysfunctionTherapeutic implicationsCognitive deficitsType 1Brain functionNeuroinflammationInflammationDysfunctionGlucoseLow levelsSystem outcomesHigh levelsComplicationsHyperglycemiaDiabetesLatest dataCharacterizing the Effects of Diabetes and Obesity on Insulin and Leptin Levels amongst Pregnant Women
Johnson AW, Snegovskikh D, Parikh L, DeAguiar RB, Han CS, Hwang JJ. Characterizing the Effects of Diabetes and Obesity on Insulin and Leptin Levels amongst Pregnant Women. American Journal Of Perinatology 2020, 37: 1094-1101. PMID: 32120424, DOI: 10.1055/s-0040-1702988.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDiabetes mellitusLeptin levelsCerebrospinal fluidLean mothersPlasma ratioMaternal cerebrospinal fluidMaternal metabolic environmentElective cesarean deliveryImpact of obesityCord blood insulinEffect of diabetesLow cerebrospinal fluidUncomplicated singleton pregnanciesMaternal plasma ratioArtery plasmaDM mothersCesarean deliveryObese patientsSingleton pregnanciesFetal exposureBlood insulinLower cordPregnant womenMaternal brainLean individuals
2018
Verapamil is a potential therapy for hypoglycaemic brain injury
Hwang JJ, Sherwin RS. Verapamil is a potential therapy for hypoglycaemic brain injury. Nature Reviews Endocrinology 2018, 14: 443-444. PMID: 29967401, DOI: 10.1038/s41574-018-0056-7.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and Concepts
Clinical Trials
Current Trials
Impact of Hypoglycemia on Brain Ketone and Neurotransmitter Metabolism in Type 1 DM
HIC ID1208010648RoleSub InvestigatorPrimary Completion Date09/29/2022Recruiting ParticipantsGenderBothAge18+ years
Links & Media
News
- September 20, 2021
Yale Endocrinology & Metabolism Publications
- September 16, 2021
Discoveries & Impact (September 2021)
- September 10, 2019
Meet Yale Internal Medicine: Janice Jin Hwang, MD MHS, Assistant Professor of Medicine (Endocrinology).
- July 23, 2019
July 18, 2019 Medical Grand Rounds Recap