2024
Utilization of Ambulatory Blood Pressure Monitoring in Children and Adolescents With Hypertension.
Nugent JT, Kaelber DC. Utilization of Ambulatory Blood Pressure Monitoring in Children and Adolescents With Hypertension. Pediatrics 2024 PMID: 39385675, DOI: 10.1542/peds.2024-067463.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsThe Study of the Epidemiology of Pediatric Hypertension Registry (SUPERHERO): rationale and methods
South A, Giammattei V, Bagley K, Bakhoum C, Beasley W, Bily M, Biswas S, Bridges A, Byfield R, Campbell J, Chanchlani R, Chen A, McGowan L, Downs S, Fergeson G, Greenberg J, Hill-Horowitz T, Jensen E, Kallash M, Kamel M, Kiessling S, Kline D, Laisure J, Liu G, Londeree J, Lucas C, Mannemuddhu S, Mao K, Misurac J, Murphy M, Nugent J, Onugha E, Pudupakkam A, Redmond K, Riar S, Sethna C, Siddiqui S, Thumann A, Uss S, Vincent C, Viviano I, Walsh M, White B, Woroniecki R, Wu M, Yamaguchi I, Yun E, Weaver D. The Study of the Epidemiology of Pediatric Hypertension Registry (SUPERHERO): rationale and methods. American Journal Of Epidemiology 2024, kwae116. PMID: 38881045, DOI: 10.1093/aje/kwae116.Peer-Reviewed Original ResearchManual record reviewHypertensive disordersRecord reviewElectronic health record dataICD-10Health record dataInternational Classification of Diseases diagnostic codesReduce CVD burdenPrevalence of hypertensionIncreased prevalence of hypertensionCardiovascular mortality ratesCVD burdenBlood pressureInternational ClassificationDiagnostic codesClinical careRecord dataInclusion criteriaLife courseIncreased prevalencePediatric hypertensionLong-term consequencesMortality rateEpidemiologyBiomedical informaticsHigh Blood Pressure in Children Aged 3 to 12 Years Old With Overweight or Obesity
Nugent J, Maciejewski K, Finn E, Grout R, Wood C, Esserman D, Michel J, Lu Y, Sharifi M. High Blood Pressure in Children Aged 3 to 12 Years Old With Overweight or Obesity. Childhood Obesity 2024 PMID: 38700557, DOI: 10.1089/chi.2023.0143.Peer-Reviewed Original ResearchHypertensive BPHigh blood pressurePrevalence of high blood pressurePrimary care practicesAssociated with higher oddsUS health systemBlood pressureSustained hypertensionPre-intervention dataAged 3Multivariate logistic regressionStudy periodObesity practiceChildren aged 3Care practicesBMI classificationHealth systemBP percentilesHigher oddsDiagnosing sustained hypertensionObesity severityOverweight/obesityLogistic regressionHigh BPIII obesityCOVID-19−Associated Acute Kidney Injury and Longitudinal Kidney Outcomes
Aklilu A, Kumar S, Nugent J, Yamamoto Y, Coronel-Moreno C, Kadhim B, Faulkner S, O’Connor K, Yasmin F, Greenberg J, Moledina D, Testani J, Wilson F. COVID-19−Associated Acute Kidney Injury and Longitudinal Kidney Outcomes. JAMA Internal Medicine 2024, 184: 414-423. PMID: 38407862, PMCID: PMC10897825, DOI: 10.1001/jamainternmed.2023.8225.Peer-Reviewed Original ResearchCOVID-19-associated acute kidney injuryCOVID-19-associated AKIAcute kidney injuryMulticenter cohort studyKidney function declineKidney functionKidney injuryCohort studyKidney outcomes of patientsIncidence of acute kidney injuryLong-term kidney outcomesHistorical cohort of patientsMultivariate time-to-event analysesPositive influenza ALongitudinal multicenter cohort studyWorsening kidney functionOutcomes of patientsAdverse kidney eventsCohort of patientsComposite of mortalityMarkers of illness severityAdult hospitalized patientsBaseline comorbidity scoreTime-to-event analysisFunctional decline
2023
Decoding the Association Between Body Composition in Preterm Birth and Hypertension in Childhood—Reply
Nugent J, Sharifi M, Greenberg J. Decoding the Association Between Body Composition in Preterm Birth and Hypertension in Childhood—Reply. JAMA Pediatrics 2023, 177: 1239-1240. PMID: 37695615, DOI: 10.1001/jamapediatrics.2023.3519.Peer-Reviewed Original ResearchDiagnostic Yield of Kidney Ultrasound in Children Evaluated for Hypertension
Nugent J, Crana C, Greenberg J. Diagnostic Yield of Kidney Ultrasound in Children Evaluated for Hypertension. Clinical Pediatrics 2023, 63: 604-607. PMID: 37560884, DOI: 10.1177/00099228231191922.Peer-Reviewed Original ResearchEffect Measure Modification by Birth Weight on the Association Between Overweight or Obesity and Hypertension in Children and Adolescents
Nugent J, Lu Y, Deng Y, Sharifi M, Greenberg J. Effect Measure Modification by Birth Weight on the Association Between Overweight or Obesity and Hypertension in Children and Adolescents. JAMA Pediatrics 2023, 177: 735-737. PMID: 37155182, PMCID: PMC10167596, DOI: 10.1001/jamapediatrics.2023.0799.Peer-Reviewed Original ResearchHypertension, Blood Pressure Variability, and Acute Kidney Injury in Hospitalized Children
Nugent J, Ghazi L, Yamamoto Y, Bakhoum C, Wilson F, Greenberg J. Hypertension, Blood Pressure Variability, and Acute Kidney Injury in Hospitalized Children. Journal Of The American Heart Association 2023, 12: e029059. PMID: 37119062, PMCID: PMC10227226, DOI: 10.1161/jaha.122.029059.Peer-Reviewed Original ResearchConceptsAcute kidney injuryBlood pressure variabilityBlood pressure measurementsHospitalized childrenKidney injuryBlood pressurePressure variabilityIncident acute kidney injuryTime-updated Cox modelsMean blood pressureEnd-organ complicationsAnalysis of hypertensionAKI riskConclusions HypertensionHypertension thresholdInpatient hypertensionNormotensive patientsOrgan complicationsNonpharmacologic interventionsRetrospective cohortPediatric inpatientsMultivariable modelPediatric encountersHypertensionCox modelDoes This Child With High Blood Pressure Have Secondary Hypertension?
Nugent J, Jiang K, Funaro M, Saran I, Young C, Ghazi L, Bakhoum C, Wilson F, Greenberg J. Does This Child With High Blood Pressure Have Secondary Hypertension? JAMA 2023, 329: 1012-1021. PMID: 36976276, DOI: 10.1001/jama.2023.3184.Peer-Reviewed Original ResearchConceptsBlood pressure loadAmbulatory blood pressure monitoringSecondary hypertensionBlood pressure monitoringPrimary hypertensionFamily historyBlood pressurePressure monitoringDiastolic blood pressure loadSystolic blood pressure loadSerum uric acid concentrationAmbulatory blood pressureHigh blood pressureHistory of prematurityPrimary care clinicsRisk of biasNumber of patientsDatabases of MEDLINEDiagnostic Accuracy Studies toolLower body weightRandom-effects modelingUric acid concentrationWeb of ScienceLikelihood ratioAsymptomatic presentation
2022
Effect of intravenous antihypertensives on outcomes of severe hypertension in hospitalized patients without acute target organ damage
Ghazi L, Li F, Simonov M, Yamamoto Y, Nugent J, Greenberg J, Bakhoum C, Peixoto A, Wilson F. Effect of intravenous antihypertensives on outcomes of severe hypertension in hospitalized patients without acute target organ damage. Journal Of Hypertension 2022, 41: 288-294. PMID: 36583354, PMCID: PMC9799038, DOI: 10.1097/hjh.0000000000003328.Peer-Reviewed Original ResearchConceptsAcute target organ damageTarget organ damageSevere hypertensionOrgan damageIntravenous antihypertensivesBP elevationClinical outcomesMyocardial injuryTarget end-organ damageOverlap propensity scoreSevere BP elevationAcute kidney injuryBlood pressure reductionEnd-organ damageRisk of strokeInpatient hypertensionCardiovascular eventsIndex hospitalizationKidney injuryRetrospective studyHypertensionAntihypertensivesHospitalizationCox modelPatientsAntihypertensive Treatment and Clinical Outcomes Among Patients Who Develop Severe Hypertension During Hospitalization
Ghazi, Nugent J, Greenberg J, Bakhoum C, Wilson F. Antihypertensive Treatment and Clinical Outcomes Among Patients Who Develop Severe Hypertension During Hospitalization. Journal Of The American Society Of Nephrology 2022, 33: 528-528. DOI: 10.1681/asn.20223311s1528a.Peer-Reviewed Original ResearchAdherence to Guidelines for Management of Hypertensive Emergency
Ghazi, Nugent J, Castro A, Wilson F. Adherence to Guidelines for Management of Hypertensive Emergency. Journal Of The American Society Of Nephrology 2022, 33: 216-217. DOI: 10.1681/asn.20223311s1216c.Peer-Reviewed Original ResearchAn unusual cause of relapsing peritonitis in a patient on peritoneal dialysis
Nugent JT, Crana C, Warejko JK. An unusual cause of relapsing peritonitis in a patient on peritoneal dialysis. Seminars In Dialysis 2022, 35: 561-562. PMID: 35460112, DOI: 10.1111/sdi.13090.Peer-Reviewed Original ResearchScreening for Hypertension in Children With and Without Autism Spectrum Disorder
Nugent JT, Bakhoum C, Ghazi L, Greenberg JH. Screening for Hypertension in Children With and Without Autism Spectrum Disorder. JAMA Network Open 2022, 5: e226246. PMID: 35385092, PMCID: PMC8987909, DOI: 10.1001/jamanetworkopen.2022.6246.Peer-Reviewed Original ResearchPrevalence of Secondary Hypertension in Otherwise Healthy Youths with a New Diagnosis of Hypertension: A Meta-Analysis
Nugent JT, Young C, Funaro MC, Jiang K, Saran I, Ghazi L, Wilson FP, Greenberg JH. Prevalence of Secondary Hypertension in Otherwise Healthy Youths with a New Diagnosis of Hypertension: A Meta-Analysis. The Journal Of Pediatrics 2022, 244: 30-37.e10. PMID: 35120981, PMCID: PMC9086113, DOI: 10.1016/j.jpeds.2022.01.047.Peer-Reviewed Original ResearchConceptsSecondary hypertensionPrimary careLow prevalenceNew diagnosisTime of diagnosisClinical practice guidelinesCochrane Library databasesBlood pressure deviceSignificant subgroup differencesParticipants' age rangeWeb of ScienceHypertension definitionReferral clinicProspective studyRetrospective studyOutpatient settingHealthy childrenSecondary causesCurrent guidelinesDiagnostic evaluationHypertensionObservational studyPractice guidelinesLibrary databasesPrevalence estimates
2021
Fanconi syndrome, nephrotic-range proteinuria, and hypoalbuminemia in a newborn—Occam’s razor or Hickam’s dictum? Questions
Nugent JT, Reardon J, Crana C, Greenberg JH, Warejko JK, Goodwin JE. Fanconi syndrome, nephrotic-range proteinuria, and hypoalbuminemia in a newborn—Occam’s razor or Hickam’s dictum? Questions. Pediatric Nephrology 2021, 37: 127-128. PMID: 34633531, DOI: 10.1007/s00467-021-05247-w.Peer-Reviewed Case Reports and Technical NotesFanconi syndrome, nephrotic-range proteinuria, and hypoalbuminemia in a newborn—Occam’s razor or Hickam’s dictum? Answers
Nugent JT, Reardon J, Crana C, Greenberg JH, Warejko JK, Goodwin JE. Fanconi syndrome, nephrotic-range proteinuria, and hypoalbuminemia in a newborn—Occam’s razor or Hickam’s dictum? Answers. Pediatric Nephrology 2021, 37: 129-132. PMID: 34633532, DOI: 10.1007/s00467-021-05255-w.Peer-Reviewed Case Reports and Technical NotesPrevalence of Secondary Hypertension in Children with a New Diagnosis of Hypertension: A Meta-Analysis
Nugent J, Young C, Funaro M, Ghazi, Wilson F, Greenberg J. Prevalence of Secondary Hypertension in Children with a New Diagnosis of Hypertension: A Meta-Analysis. Journal Of The American Society Of Nephrology 2021, 32: 837-838. DOI: 10.1681/asn.20213210s1837c.Peer-Reviewed Original ResearchAssessment of Acute Kidney Injury and Longitudinal Kidney Function After Hospital Discharge Among Patients With and Without COVID-19
Nugent J, Aklilu A, Yamamoto Y, Simonov M, Li F, Biswas A, Ghazi L, Greenberg J, Mansour S, Moledina D, Wilson FP. Assessment of Acute Kidney Injury and Longitudinal Kidney Function After Hospital Discharge Among Patients With and Without COVID-19. JAMA Network Open 2021, 4: e211095. PMID: 33688965, PMCID: PMC7948062, DOI: 10.1001/jamanetworkopen.2021.1095.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAged, 80 and overBlack or African AmericanCohort StudiesComorbidityCOVID-19CreatinineFemaleFollow-Up StudiesGlomerular Filtration RateHispanic or LatinoHumansHypertensionKidney Function TestsLongitudinal StudiesMaleMiddle AgedPatient DischargeProportional Hazards ModelsRenal Insufficiency, ChronicRetrospective StudiesSARS-CoV-2United StatesConceptsCOVID-19-associated acute kidney injuryAcute kidney injuryHospital acute kidney injurySubgroup of patientsKidney functionKidney injuryCohort studyHospital dischargeAKI recoveryKidney diseaseCOVID-19Peak creatinine levelsRetrospective cohort studyChronic kidney diseaseDays of dischargeHalf of patientsGlomerular filtration rateCoronavirus disease 2019AKI severityBaseline comorbiditiesEGFR decreaseDialysis requirementEGFR slopeKidney recoveryCreatinine levels
2019
Reporting of race in genome and exome sequencing studies of cancer: a scoping review of the literature.
Nugent A, Conatser KR, Turner LL, Nugent JT, Sarino EMB, Ricks-Santi LJ. Reporting of race in genome and exome sequencing studies of cancer: a scoping review of the literature. Genetics In Medicine : Official Journal Of The American College Of Medical Genetics 2019, 21: 2676-2680. PMID: 31160752, PMCID: PMC6891161, DOI: 10.1038/s41436-019-0558-2.Peer-Reviewed Original Research