2020
Su1147 PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) PATIENT-DERIVED TUMOR ORGANOID (PDTO) GENERATION BY EUS-FNB IS FEASIBLE IN PATIENTS PREVIOUSLY TREATED WITH CHEMOTHERAPY
Yoo J, Nair G, Kesar V, Foster G, Joshi N, Farrell J. Su1147 PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) PATIENT-DERIVED TUMOR ORGANOID (PDTO) GENERATION BY EUS-FNB IS FEASIBLE IN PATIENTS PREVIOUSLY TREATED WITH CHEMOTHERAPY. Gastroenterology 2020, 158: s-524. DOI: 10.1016/s0016-5085(20)31997-1.Peer-Reviewed Original ResearchPancreatic Cancer; Biomolecular and Genetic Aspects
Yoo J, Farrell J. Pancreatic Cancer; Biomolecular and Genetic Aspects. 2020, 30-38. DOI: 10.1016/b978-0-12-801238-3.65864-6.Peer-Reviewed Original ResearchPancreatic cancerGenetic aspectsNext-generation sequencingTranscriptomic analysisGenomic investigationsKey driver mutationsRecent translational advancesOverall survival rateMutational landscapeDiscrete molecular subtypesGeneration sequencingSpecific therapyLethal malignancyMolecular subtypesDisease processDriver mutationsSurvival rateTranslational advancesCancerPrecision medicineBiomolecularSequencingMutationsPathwayPatients
2019
Updated international Cancer of the Pancreas Screening (CAPS) consortium guidelines on the management of patients with increased risk for familial pancreatic cancer
Overbeek K, Canto M, Bartsch D, Brand R, Carrato A, Del Chiaro M, Farrell J, Fishman E, Fockens P, Gress T, van Hooft J, Kastrinos F, Rustgi A, Syngal S, Vasen H, Cahen D, Bruno M, Goggins M, Consortium I. Updated international Cancer of the Pancreas Screening (CAPS) consortium guidelines on the management of patients with increased risk for familial pancreatic cancer. Pancreatology 2019, 19: s56-s57. DOI: 10.1016/j.pan.2019.05.143.Peer-Reviewed Original ResearchSa1350 – Updated International Cancer of the Pancreas Screening (CAPS) Consortium Guidelines on the Management of Patients with Increased Risk for Familial Pancreatic Cancer
Overbeek K, Canto M, Bartsch D, Brand R, Carrato A, Del Chiaro M, Farrell J, Fishman E, Fockens P, Gress T, van Hooft J, Kastrinos F, Rustgi A, Syngal S, Vasen H, Cahen D, Bruno M, Goggins M. Sa1350 – Updated International Cancer of the Pancreas Screening (CAPS) Consortium Guidelines on the Management of Patients with Increased Risk for Familial Pancreatic Cancer. Gastroenterology 2019, 156: s-323. DOI: 10.1016/s0016-5085(19)37637-1.Peer-Reviewed Original Research
2018
Incremental value of DNA analysis in pancreatic cysts stratified by clinical risk factors
Farrell J, Al-Haddad M, Jackson SA, Gonda T. Incremental value of DNA analysis in pancreatic cysts stratified by clinical risk factors. Gastrointestinal Endoscopy 2018, 89: 832-841.e2. PMID: 30447214, DOI: 10.1016/j.gie.2018.10.049.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaCyst FluidDNAEndoscopic Ultrasound-Guided Fine Needle AspirationFollow-Up StudiesGenes, Tumor SuppressorHumansKaplan-Meier EstimateLoss of HeterozygosityMutationPancreatic CystPancreatic NeoplasmsProportional Hazards ModelsProto-Oncogene Proteins p21(ras)Retrospective StudiesRisk AssessmentRisk FactorsSequence Analysis, DNASurvival AnalysisConceptsHigh-risk stigmataWorrisome featuresMalignancy riskPatient outcomesDNA abnormalitiesPredictive valueCyst fluid molecular analysisLong-term malignancy riskClinical risk factorsIncremental predictive valueCytologic malignancyClinical characteristicsFinal pathologyFree survivalSuch patientsPatient populationPancreatic cystsRisk factorsMalignant outcomeCyst fluidKras mutationsPatientsSurvival analysisAbnormalitiesTumor suppressor gene
2017
Advanced Endoscopic Procedures
Farrell J. Advanced Endoscopic Procedures. 2017, 151-169. DOI: 10.1007/978-3-319-58256-6_8.Peer-Reviewed Original ResearchAdvanced endoscopic proceduresEndoscopic retrograde cholangiopancreatographyPancreatic cancerEndoscopic proceduresEndoscopic ultrasoundMultidisciplinary management approachManagement of patientsPalliation of patientsEndoscopic enteral stent placementEnteral stent placementRetrograde cholangiopancreatographySurgical approachStent placementCancerPatientsPalliationCholangiopancreatographyDiagnosis
2007
Risk of Malignancy in Resected Cystic Tumors of the Pancreas ≤3 cm in Size: Is it Safe to Observe Asymptomatic Patients? A Multi-institutional Report
Lee C, Scheiman J, Anderson M, Hines O, Reber H, Farrell J, Kochman M, Foley P, Drebin J, Oh Y, Ginsberg G, Ahmad N, Merchant N, Isbell J, Parikh A, Stokes J, Bauer T, Adams R, Simeone D. Risk of Malignancy in Resected Cystic Tumors of the Pancreas ≤3 cm in Size: Is it Safe to Observe Asymptomatic Patients? A Multi-institutional Report. Journal Of Gastrointestinal Surgery 2007, 12: 234-242. PMID: 18040749, DOI: 10.1007/s11605-007-0381-y.Peer-Reviewed Original ResearchConceptsCystic pancreatic tumorsPancreatic resectionFemale patientsCystic neoplasmsRadiographic featuresPancreatic tumorsRecent international consensus guidelinesHigh-volume pancreatic centersPancreatic resection databaseGroup of patientsInternational consensus guidelinesPresence of malignancyPrevalence of malignancyMagnetic resonance imagingAsymptomatic patientsMale patientsPancreatic centersConsensus guidelinesPathological dataMalignant pathologyEndoscopic ultrasoundHigh incidencePatientsMalignancyGreater incidence
2002
Endoscopic mucosal resection for gastric neoplasms
Farrell J, Brugge W. Endoscopic mucosal resection for gastric neoplasms. Techniques And Innovations In Gastrointestinal Endoscopy 2002, 4: 34-41. DOI: 10.1053/tgie.2002.31949.Peer-Reviewed Original ResearchEndoscopic mucosal resectionSuperficial gastric cancerMucosal resectionGastric cancerGastric endoscopic mucosal resectionLong-term clinical outcomesLong-term survival ratesResection of mucosaLong-term outcomesTreatment of patientsAssociated postoperative morbidityCurative intentPostoperative morbidityClinical outcomesGastric neoplasmsSurvival rateResectionSurgeryInvasive surgeryStrict criteriaPatientsCancerOutcomesTreatmentMorbidity
2001
DIVERTICULAR DISEASE IN THE ELDERLY
Farrell R, Farrell J, Morrin M. DIVERTICULAR DISEASE IN THE ELDERLY. Gastroenterology Clinics Of North America 2001, 30: 475-496. PMID: 11432301, DOI: 10.1016/s0889-8553(05)70191-6.Peer-Reviewed Original Research