Antibody-mediated transduction of p53 selectively kills cancer cells.
Weisbart RH, Hansen JE, Chan G, Wakelin R, Chang SS, Heinze E, Miller CW, Koeffler PH, Yang F, Cole GM, Min YS, Nishimura RN. Antibody-mediated transduction of p53 selectively kills cancer cells. International Journal Of Oncology 2004, 25: 1867-73. PMID: 15547728, DOI: 10.3892/ijo.25.6.1867.Peer-Reviewed Original ResearchConceptsCancer cellsWild-type p53Expression of MDM2Cancer cell linesTransduction of p53Potential efficacyCertain cancersNon-specific toxicityFunctional defectsHuman cancersP53Cell linesCancerResult of mutationsGene therapyPrimary cellsViral vectorsCellsVivoNuclear exclusionTherapyFusion proteinFv fragmentProtein transductionAntibodies