2011
mTOR Controls Ovarian Follicle Growth by Regulating Granulosa Cell Proliferation
Yu J, Yaba A, Kasiman C, Thomson T, Johnson J. mTOR Controls Ovarian Follicle Growth by Regulating Granulosa Cell Proliferation. PLOS ONE 2011, 6: e21415. PMID: 21750711, PMCID: PMC3130037, DOI: 10.1371/journal.pone.0021415.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsApoptosisBlotting, WesternCarrier ProteinsCell DivisionCell Line, TransformedCell ProliferationDose-Response Relationship, DrugFemaleFlow CytometryG1 PhaseGranulosa CellsImmunosuppressive AgentsMaleMiceMice, Inbred C57BLOvarian FolliclePhosphorylationRatsRegulatory-Associated Protein of mTORRibosomal Protein S6 Kinases, 70-kDaSirolimusTOR Serine-Threonine KinasesConceptsAberrant mitotic figuresGranulosa cellsFollicle growthMitotic figuresMice treated with rapamycinFraction of granulosa cellsEffects of mTOR inhibitionRegulation of follicle growthDose-dependent increaseDose-dependent reductionRegulating granulosa cell proliferationGranulosa cell proliferationReduced compared to controlsMTOR pathway activationAberrant mitotic eventsExpression of RaptorOvarian follicle growthOvarian folliclesInhibition of mTORPresence of rapamycinMTOR inhibitionGranulosaInhibitor rapamycinConsequences of increased numbersMitotic index
2005
Phosphorylated FADD induces NF-κB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas
Chen G, Bhojani M, Heaford A, Chang D, Laxman B, Thomas D, Griffin L, Yu J, Coppola J, Giordano T, Lin L, Adams D, Orringer M, Ross B, Beer D, Rehemtulla A. Phosphorylated FADD induces NF-κB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 12507-12512. PMID: 16109772, PMCID: PMC1194899, DOI: 10.1073/pnas.0500397102.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdenocarcinomaApoptosisCell CycleCell NucleusCell ProliferationDNA, NeoplasmElectrophoresis, Gel, Two-DimensionalFas-Associated Death Domain ProteinGene AmplificationGene ExpressionHumansJurkat CellsLung NeoplasmsMutationNF-kappa BOligonucleotide Array Sequence AnalysisPhosphorylationPrognosisRNA, MessengerRNA, NeoplasmRNA, Small InterferingSerineConceptsFas-associated death domainCell cycle progressionP-FADDCell cyclePhosphorylated Fas associated death domainAnalysis of copy numberRegulation of cell cycle progressionNF-kappaB activationNF-kappaBPerturbed cell cycleElevated NF-kappaBCDNA microarray analysisInduction of NF-kappaB activityFADD geneDeath domainNonphosphorylatable formPoor outcomeLung cancerCDNA microarrayLung adenocarcinomaNuclear localizationCycle progressionCopy numberTissue microarray analysisAssociated with poor survival