2018
Placental growth factor (PlGF) is linked to inflammation and metabolic disorders in mice with diet-induced obesity
Kang M, Jeong J, Lee J, Park S, Sung Y, Choi M, Kwon W, Jang S, Choi K, Choo Y, Yoon D, Kim M, Ryoo Z. Placental growth factor (PlGF) is linked to inflammation and metabolic disorders in mice with diet-induced obesity. Endocrine Journal 2018, 65: ej17-0363. PMID: 29434073, DOI: 10.1507/endocrj.ej17-0363.Peer-Reviewed Original ResearchMeSH KeywordsAdiposityAnimalsCytokinesDiet, High-FatInflammationInsulin ResistanceMiceMice, TransgenicObesityPlacenta Growth FactorConceptsHigh-fat dietDiet-induced obesityCD3/CD28 stimulationEpididymal white adipose tissueObesity-induced inflammationPlacental growth factorVascular endothelial growth factorT cellsMetabolic disordersTg miceT cell differentiationAdipose tissueHFD miceGrowth factorCD28 stimulationInflammatory T cell differentiationPro-inflammatory cytokines IL-6Mice fed high-fat dietType 17 helper T cellsFed high-fat dietWT-HFD miceSystemic metabolic disordersIsolated T lymphocytesHelper T cellsCytokines IL-6
2016
Serum amyloid A1 levels and amyloid deposition following a high-fat diet challenge in transgenic mice overexpressing hepatic serum amyloid A1
Jang W, Jeong J, Kim S, Kang M, Sung Y, Choi M, Park S, Kim M, Kim S, Ryoo Z. Serum amyloid A1 levels and amyloid deposition following a high-fat diet challenge in transgenic mice overexpressing hepatic serum amyloid A1. Applied Physiology Nutrition And Metabolism 2016, 41: 640-648. PMID: 27218680, DOI: 10.1139/apnm-2015-0369.Peer-Reviewed Original ResearchConceptsHigh-fat dietSAA1 levelsAmyloid depositionTg miceMetabolic disturbancesTransgenic miceHepatic serum amyloid A1Elevated levelsImpaired glucose toleranceLow-grade inflammationLocal cytokine expressionChronic inflammatory conditionsHigh-fat diet challengeSerum amyloid A1Acute phase response proteinsMajor precursor proteinCrohn's diseaseGlucose toleranceCytokine expressionInflammatory conditionsMetabolic parametersSerum amyloidMetabolic disordersAmyloid depositsDiet challenge
2013
Overexpression of Jazf1 reduces body weight gain and regulates lipid metabolism in high fat diet
Jang W, Bae K, Kim S, Yu D, Kim H, Ji Y, Park S, Park S, Kang M, Jeong J, Park S, Lee S, Lee I, Kim M, Yoon D, Ryoo Z. Overexpression of Jazf1 reduces body weight gain and regulates lipid metabolism in high fat diet. Biochemical And Biophysical Research Communications 2013, 444: 296-301. PMID: 24380856, DOI: 10.1016/j.bbrc.2013.12.094.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood GlucoseCarrier ProteinsCo-Repressor ProteinsDiet, High-FatDNA-Binding ProteinsGlucose Tolerance TestHomeostasisInsulinLipid MetabolismMiceMice, TransgenicNuclear ProteinsPhosphoenolpyruvate Carboxykinase (GTP)Real-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionWeight GainConceptsPutative zinc finger motifZinc finger motifsNuclear orphan receptor TR4Regulation of metabolismOverexpression of JAZF1Finger motifTranscription factorsNuclear proteinsKey enzymeExpression of JAZF1Lipid homeostasisFat dietNew therapeutic targetsWeight gainLipid accumulationManagement of obesityHigh-fat dietCritical roleJAZF1Lipid metabolismTherapeutic targetBody weight gainMetabolismRegulationDiabetes mellitus