2020
IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells
Lee J, Robinson ME, Ma N, Artadji D, Ahmed MA, Xiao G, Sadras T, Deb G, Winchester J, Cosgun KN, Geng H, Chan LN, Kume K, Miettinen TP, Zhang Y, Nix MA, Klemm L, Chen CW, Chen J, Khairnar V, Wiita AP, Thomas-Tikhonenko A, Farzan M, Jung JU, Weinstock DM, Manalis SR, Diamond MS, Vaidehi N, Müschen M. IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells. Nature 2020, 588: 491-497. PMID: 33149299, PMCID: PMC8087162, DOI: 10.1038/s41586-020-2884-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CD19B-LymphocytesCell Transformation, NeoplasticFemaleGerminal CenterHumansIntegrinsMembrane MicrodomainsMembrane ProteinsMiceMice, Inbred C57BLMice, Inbred NODModels, MolecularPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhosphorylationReceptors, Antigen, B-CellRNA-Binding ProteinsSignal TransductionConceptsPI3KCell leukemiaAntiviral effector functionsAntigen-specific antibodiesInterferon-induced transmembrane proteinsIFITM3 functionDevelopment of leukemiaCell surfacePoor outcomeOncogenic PI3KClinical cohortEffector functionsGerminal centersMouse modelB cellsExpression of IFITM3Malignant transformationAccumulation of PIP3PI3K signalsCell receptorNormal numbersLeukemiaDefective expressionEndosomal proteinIFITM3
2013
Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile
Cramer-Morales K, Nieborowska-Skorska M, Scheibner K, Padget M, Irvine DA, Sliwinski T, Haas K, Lee J, Geng H, Roy D, Slupianek A, Rassool FV, Wasik MA, Childers W, Copland M, Müschen M, Civin CI, Skorski T. Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile. Blood 2013, 122: 1293-1304. PMID: 23836560, PMCID: PMC3744994, DOI: 10.1182/blood-2013-05-501072.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisAptamers, PeptideBiomarkers, TumorBlotting, WesternBRCA1 ProteinBRCA2 ProteinCase-Control StudiesCell DifferentiationCell ProliferationDNA DamageDNA RepairEpigenomicsFusion Proteins, bcr-ablGene Expression ProfilingHumansLeukemia, Lymphocytic, Chronic, B-CellMiceMice, SCIDModels, MolecularMutationNeoplasm Recurrence, LocalNeoplastic Stem CellsOligonucleotide Array Sequence AnalysisPeptide FragmentsRad51 RecombinaseRad52 DNA Repair and Recombination ProteinReal-Time Polymerase Chain ReactionRecombination, GeneticReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTumor Cells, CulturedXenograft Model Antitumor Assays