Acidic Mammalian Chitinase Regulates Epithelial Cell Apoptosis via a Chitinolytic-Independent Mechanism
Hartl D, He CH, Koller B, Da Silva CA, Kobayashi Y, Lee CG, Flavell RA, Elias JA. Acidic Mammalian Chitinase Regulates Epithelial Cell Apoptosis via a Chitinolytic-Independent Mechanism. The Journal Of Immunology 2009, 182: 5098-5106. PMID: 19342690, PMCID: PMC2666938, DOI: 10.4049/jimmunol.0803446.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCell Line, TumorChitinChitinasesEnzyme ActivationEpithelial CellsGene Expression Regulation, EnzymologicHumansInterleukin-13LungMiceMice, Inbred C57BLMice, TransgenicProtein BindingProto-Oncogene Proteins c-aktConceptsAcidic mammalian chitinaseTh2-mediated diseasesEpithelial cellsMammalian chitinasePI3K/Akt pathwayPulmonary epithelial cellsEpithelial cell apoptosisApoptosis-inhibiting effectsComparable cytoprotectionGrowth factor withdrawal-induced apoptosisChitinolytic activityEffector responsesParacrine mannerFas ligand-induced apoptosisAntiparasite responsesGrowth factor withdrawalWithdrawal-induced apoptosisLigand-induced apoptosisFas ligandAkt pathwayCell apoptosisAkt phosphorylationAMCaseBiologic propertiesCytoprotection