2009
Mathematical modeling of a minimal protocell with coordinated growth and division
Surovtsev I, Zhang Z, Lindahl P, Morgan J. Mathematical modeling of a minimal protocell with coordinated growth and division. Journal Of Theoretical Biology 2009, 260: 422-429. PMID: 19501600, DOI: 10.1016/j.jtbi.2009.06.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArtificial CellsCell CycleCell DivisionCell MembraneCell ShapeCytoskeletal ProteinsModels, BiologicalConceptsCellular componentsDaughter cellsWhole-cell modeling frameworkParental cellsCell cycle engineMinimal protocellWhole-cell modelsContractile ringCoordinated growthCell shapeCell cycleCellular geometryMembrane areaProtocellsMolecular-level mechanismsCellsSimultaneous doublingCytokinesisCell volume
2008
Kinetic Modeling of the Assembly, Dynamic Steady State, and Contraction of the FtsZ Ring in Prokaryotic Cytokinesis
Surovtsev I, Morgan J, Lindahl P. Kinetic Modeling of the Assembly, Dynamic Steady State, and Contraction of the FtsZ Ring in Prokaryotic Cytokinesis. PLOS Computational Biology 2008, 4: e1000102. PMID: 18604268, PMCID: PMC2432035, DOI: 10.1371/journal.pcbi.1000102.Peer-Reviewed Original ResearchConceptsSame chemical modelMonomeric unitsPolymeric ringsRapid assemblyChemical modelProkaryotic cytokinesisMembrane surfaceFree energyUnfavorable processMonomeric FtsZKinetic modelingMechanistic complexityInterfacial reactionRingVivo behaviorDynamic steady stateMonomeric subunitsFtsZ polymerizationHydrolysisReactionRing formsAssembly