2016
Replication fork passage drives asymmetric dynamics of a critical nucleoid‐associated protein in Caulobacter
Arias‐Cartin R, Dobihal GS, Campos M, Surovtsev IV, Parry B, Jacobs‐Wagner C. Replication fork passage drives asymmetric dynamics of a critical nucleoid‐associated protein in Caulobacter. The EMBO Journal 2016, 36: 301-318. PMID: 28011580, PMCID: PMC5286365, DOI: 10.15252/embj.201695513.Peer-Reviewed Original ResearchConceptsNucleoid-associated proteinsDNA replicationNovel nucleoid-associated proteinGene expressionReplication fork passageGlobal gene expressionCell cycle regulationDNA-binding activityCell cycle progressionChromosome dynamicsFork passageChromosome segregationPleiotropic defectsChromosomal biasCaulobacter crescentusAsymmetric localizationReplication forksCellular functionsCycle regulationGenomic techniquesQuantitative cell imagingCell divisionGapRCycle progressionCell cycle
2014
A Constant Size Extension Drives Bacterial Cell Size Homeostasis
Campos M, Surovtsev IV, Kato S, Paintdakhi A, Beltran B, Ebmeier SE, Jacobs-Wagner C. A Constant Size Extension Drives Bacterial Cell Size Homeostasis. Cell 2014, 159: 1433-1446. PMID: 25480302, PMCID: PMC4258233, DOI: 10.1016/j.cell.2014.11.022.Peer-Reviewed Original ResearchConceptsCell size homeostasisCell size controlSize homeostasisSingle-cell microscopyCell cycle controlCaulobacter crescentusAsymmetric divisionHomeostasis mechanismsBacteria Escherichia coliCell cycleEscherichia coliDifferent growth ratesCell growthCell lengthSize controlCell sizeHomeostasisBacteriaSize thresholdGrowth rateDivisionDirect experimental evidenceCrescentusSize paradigmColi
2009
Mathematical modeling of a minimal protocell with coordinated growth and division
Surovtsev I, Zhang Z, Lindahl P, Morgan J. Mathematical modeling of a minimal protocell with coordinated growth and division. Journal Of Theoretical Biology 2009, 260: 422-429. PMID: 19501600, DOI: 10.1016/j.jtbi.2009.06.001.Peer-Reviewed Original ResearchConceptsCellular componentsDaughter cellsWhole-cell modeling frameworkParental cellsCell cycle engineMinimal protocellWhole-cell modelsContractile ringCoordinated growthCell shapeCell cycleCellular geometryMembrane areaProtocellsMolecular-level mechanismsCellsSimultaneous doublingCytokinesisCell volume