1997
The Cutaneous Microcirculation: Ultrastructure and Microanatomical Organization
Braverman I. The Cutaneous Microcirculation: Ultrastructure and Microanatomical Organization. Microcirculation 1997, 4: 329-340. PMID: 9329009, DOI: 10.3109/10739689709146797.Peer-Reviewed Original ResearchConceptsLaser Doppler flowmetryDermal-subcutaneous junctionRed cell fluxCutaneous microcirculationAscending arteriolesMicrovascular segmentsSkin biopsy specimensCell fluxHorizontal plexusLight microscopic featuresSmooth muscle cellsUpper horizontal plexusNormal physiological stateRed blood cellsPapillary loopsBiopsy specimensPathogenetic mechanismsDoppler flowmetryMicrovascular elementsSkin circulationSkin disordersAbility of LDFMuscle cellsRetrograde flowArterioles
1995
The Golgi Association of Endothelial Nitric Oxide Synthase Is Necessary for the Efficient Synthesis of Nitric Oxide(∗)
Sessa W, Garca-Cardea G, Liu J, Keh A, Pollock J, Bradley J, Thiru S, Braverman I, Desai K. The Golgi Association of Endothelial Nitric Oxide Synthase Is Necessary for the Efficient Synthesis of Nitric Oxide(∗). Journal Of Biological Chemistry 1995, 270: 17641-17644. PMID: 7543089, DOI: 10.1074/jbc.270.30.17641.Peer-Reviewed Original ResearchConceptsHEK-293 cellsHeterologous expression systemEndothelial nitric oxide synthaseNovel GolgiGolgi associationExpression systemIntracellular signalsCultured endothelial cellsGolgiIntact blood vesselsEnzymeParticulate enzymeProteinEndothelial cellsCellsSynthaseNitric oxide synthaseOxide synthaseBlood vesselsCompartmentalizationNitric oxideTarget
1992
Human dermatosparaxis: a form of Ehlers-Danlos syndrome that results from failure to remove the amino-terminal propeptide of type I procollagen.
Smith L, Wertelecki W, Milstone L, Petty E, Seashore M, Braverman I, Jenkins T, Byers P. Human dermatosparaxis: a form of Ehlers-Danlos syndrome that results from failure to remove the amino-terminal propeptide of type I procollagen. American Journal Of Human Genetics 1992, 51: 235-44. PMID: 1642226, PMCID: PMC1682688.Peer-Reviewed Original ResearchConceptsAmino-terminal propeptideFragile skinType IConnective tissue disordersEhlers-Danlos syndromeLax jointsType VIIAffected animalsSkinChildrenCultured fibroblastsNormal cellsEhlers-Danlos syndrome type VIIPro alphaDisordersPropeptideAlphaDermatosparaxisProteolytic processingSepsisN-proteinaseCellsSyndromeCollagen fibrilsPseudoxanthoma-elasticum-Like Skin Changes Induced by Penicillamine
Bolognia J, Braverman I. Pseudoxanthoma-elasticum-Like Skin Changes Induced by Penicillamine. Dermatology 1992, 184: 12-18. PMID: 1558988, DOI: 10.1159/000247491.Peer-Reviewed Case Reports and Technical NotesConceptsAnterior axillary lineLong-term therapyRedundant skin foldsDermal elastic fibersFlexural areasHemorrhagic blistersLike lesionsSkin changesUninvolved skinYellow papulesAxillary lineHistologic changesLower buttockSkin lesionsSkin foldsPseudoxanthoma elasticumWilson's diseasePatientsLesionsSkin appearanceCalcium depositionPenicillamineElastic fibersDiseaseCystinuria
1990
Ultrastructural Analysis of the Endothelial-Pericyte Relationship in Diabetic Cutaneous Vessels
Braverman I, Sibley J, Keh A. Ultrastructural Analysis of the Endothelial-Pericyte Relationship in Diabetic Cutaneous Vessels. Journal Of Investigative Dermatology 1990, 95: 147-153. PMID: 2380575, DOI: 10.1111/1523-1747.ep12477903.Peer-Reviewed Original ResearchUltrastructural and Three-Dimensional Analysis of the Contractile Cells of the Cutaneous Microvasculature
Braverman I, Sibley J. Ultrastructural and Three-Dimensional Analysis of the Contractile Cells of the Cutaneous Microvasculature. Journal Of Investigative Dermatology 1990, 95: 90-96. PMID: 2366005, DOI: 10.1111/1523-1747.ep12874034.Peer-Reviewed Original ResearchMeSH KeywordsAdultArteriolesElastic TissueHumansImage Processing, Computer-AssistedMicroscopy, ElectronMuscle, Smooth, VascularSkinVenulesConceptsSmooth muscle cells
1989
Skin changes in menopause
Bolognia J, Braverman I, Rousseau M, Sarrel P. Skin changes in menopause. Maturitas 1989, 11: 295-304. PMID: 2693917, DOI: 10.1016/0378-5122(89)90026-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMenopausal womenEstrogen replacement therapyElastic fibersAge-related ultrastructural changesSun-exposed skinSun-protected skinDermal elastic fibersCutaneous signsEstrogen deprivationPremature menopauseReplacement therapySkin changesSkin signsTreatment periodCystic spacesDegenerative changesGranular degenerationSymptomsUltrastructural changesWomenMenopauseSignificant differencesPatientsPremature agingSkinUltrastructure and organization of the cutaneous microvasculature in normal and pathologic states.
Braverman I. Ultrastructure and organization of the cutaneous microvasculature in normal and pathologic states. Journal Of Investigative Dermatology 1989, 93: 2s-9s. PMID: 2666519, DOI: 10.1111/1523-1747.ep12580893.Peer-Reviewed Original ResearchUltrastructure and Organization of the Cutaneous Microvasculature in Normal and Pathologic States
Braverman I. Ultrastructure and Organization of the Cutaneous Microvasculature in Normal and Pathologic States. Journal Of Investigative Dermatology 1989, 93: s2-s9. DOI: 10.1038/jid.1989.2.Peer-Reviewed Original Research
1988
Age of onset, pattern of distribution, and histology of aneurysm development in a genetically predisposed mouse model
Brophy C, Tilson J, Braverman I, Tilson M. Age of onset, pattern of distribution, and histology of aneurysm development in a genetically predisposed mouse model. Journal Of Vascular Surgery 1988, 8: 45-48. PMID: 3385878, DOI: 10.1016/0741-5214(88)90242-x.Peer-Reviewed Original ResearchConceptsAge of onsetAneurysm developmentBlotchy miceIncidence of aneurysmsMonths of ageSmooth muscle cellsPossible therapeutic interventionsAneurysmal dilatationAneurysmal diseaseHistologic featuresMost aneurysmsMice 1Multiple aneurysmsAortic aneurysmAneurysmal developmentHistologic changesHistologic samplingGross evidenceMouse modelPattern of distributionLeft ventricleMouse aortaNormal animalsTherapeutic interventionsAneurysms
1987
Electron microscopic and immunolabeling studies of the lesional and normal skin of patients with mycosis fungoides treated by total body electron beam irradiation
Braverman I, Klein S, Grant A. Electron microscopic and immunolabeling studies of the lesional and normal skin of patients with mycosis fungoides treated by total body electron beam irradiation. Journal Of The American Academy Of Dermatology 1987, 16: 61-74. PMID: 3100584, DOI: 10.1016/s0190-9622(87)70005-x.Peer-Reviewed Original ResearchConceptsEpidermal Langerhans cellsElectron beam therapyLangerhans cellsMycosis fungoidesIndeterminate cellsNormal skinDisease courseLesional skinBeam therapySkin lesionsNonspecific skin lesionsPatient's disease courseIa-positive cellsEpidermal cell suspensionsEpidermal thymocyteClinical remissionBiopsy specimensPretreatment levelsIa antigensFungoidesTherapyLesionsSkinPatientsCells
1986
Elastic Fiber and Microvascular Abnormalities in Aging Skin
Braverman I. Elastic Fiber and Microvascular Abnormalities in Aging Skin. Dermatologic Clinics 1986, 4: 391-405. PMID: 3521985, DOI: 10.1016/s0733-8635(18)30802-7.Peer-Reviewed Original ResearchConceptsMicrovascular abnormalitiesSpecific clinical featuresElastic fiber abnormalitiesDiabetic patientsJuvenile diabeticsClinical featuresVeil cellsDiabetic skinFiber abnormalitiesMajor manifestationsIdentical abnormalitiesCutaneous agingAbnormalitiesCutaneous laxitySkinElastic fibersFunctional stateElastic fiber networkWall alterationsAlterationsAging processDiabeticsLikely correlatePatientsAtrophy
1985
The Response of Psoriatic Epidermis and Microvessels to Treatment with Topical Steroids and Oral Methotrexate
Braverman I, Sibley J. The Response of Psoriatic Epidermis and Microvessels to Treatment with Topical Steroids and Oral Methotrexate. Journal Of Investigative Dermatology 1985, 85: 584-586. PMID: 4067330, DOI: 10.1111/1523-1747.ep12283604.Peer-Reviewed Original ResearchConceptsOral methotrexateTopical steroidsLabeling indexPsoriatic epidermisInitial clinical improvementPlastic wrap occlusionTopical steroid therapyBasal cellsLack of responseGoeckerman treatmentSteroid therapyClinical relapseClinical improvementPsoriatic patientsPsoriatic plaquesSuccessful therapyDermal capillariesCapillary ultrastructureMethotrexateModerate acanthosisCapillary loopsSteroidsDermal papillaTherapyMicrovessels
1984
Ultrastructural Abnormalities of the Microvasculature and Elastic Fibers in the Skin of Juvenile Diabetics
Braverman I, Keh-Yen A. Ultrastructural Abnormalities of the Microvasculature and Elastic Fibers in the Skin of Juvenile Diabetics. Journal Of Investigative Dermatology 1984, 82: 270-274. PMID: 6699427, DOI: 10.1111/1523-1747.ep12260279.Peer-Reviewed Original ResearchConceptsElastic fiber abnormalitiesJuvenile diabeticsFiber abnormalitiesVascular wallUnderlying metabolic derangementsBasement membrane-like materialMetabolic derangementsIndividuals 50Buttock skinDiabetic skinPeripheral depositionUltrastructural abnormalitiesMembrane-like materialAbnormalitiesDiabeticsBasement membraneSkinElastic fibers
1983
Ultrastructure and Three-Dimensional Reconstruction of Several Macular and Papular Telangiectases
Braverman I, Keh-Yen A. Ultrastructure and Three-Dimensional Reconstruction of Several Macular and Papular Telangiectases. Journal Of Investigative Dermatology 1983, 81: 489-497. PMID: 6417247, DOI: 10.1111/1523-1747.ep12522736.Peer-Reviewed Original Research
1982
Studies in Cutaneous Aging II. The Microvasculature
Braverman I, Fonferko E. Studies in Cutaneous Aging II. The Microvasculature. Journal Of Investigative Dermatology 1982, 78: 444-448. PMID: 7069222, DOI: 10.1111/1523-1747.ep12508027.Peer-Reviewed Original ResearchConceptsVeil cellsBasement membrane-like materialButtock skinVascular wallMicrocirculatory vesselsMembrane-like materialVascular wall thickeningThin-walled vesselsDiabetes mellitusAging IIActinic damagePsoriatic individualsIndividuals 80Chronological agingPostcapillary venulesWall thickeningPeripheral portionVenous capillariesProgressive agingSkinRough endoplasmic reticulumEarly phaseWalled vesselsVesselsCellsStudies in Cutaneous Aging: I. The Elastic Fiber Network
Braverman I, Fonferko E. Studies in Cutaneous Aging: I. The Elastic Fiber Network. Journal Of Investigative Dermatology 1982, 78: 434-443. PMID: 7069221, DOI: 10.1111/1523-1747.ep12507866.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAgingChildElastic TissueFemaleHumansMaleMicroscopy, ElectronMiddle AgedPsoriasisSkinSkin Physiological PhenomenaSunlightConceptsButtock skinActinic damageCutaneous agingElastic fibersElastic fiber degradationInflammatory cellsAge 50Age 70Psoriatic individualsChronological agingAge 30Young adultsPorcine pancreatic elastaseAbnormalitiesSkinPancreatic elastaseElastaseElastic fiber networkDifferent agesAgingMorphological evidenceDamage
1975
Demonstration of Immune Complexes in Spontaneous and Histamine-Induced Lesions and in Normal Skin of Patients with Leukocytoclastic Angiitis
Braverman I, Yen A. Demonstration of Immune Complexes in Spontaneous and Histamine-Induced Lesions and in Normal Skin of Patients with Leukocytoclastic Angiitis. Journal Of Investigative Dermatology 1975, 64: 105-112. PMID: 123546, DOI: 10.1111/1523-1747.ep12510321.Peer-Reviewed Original ResearchConceptsHistamine-induced whealElectron-dense depositsImmune complexesUninvolved skinSpontaneous lesionsDirect immunofluorescenceImmune reactantsImmune complex pathogenesisImmune complex diseaseVessel wallLeukocytoclastic angiitisHistopathologic changesComplex pathogenesisLocal injectionNormal skinPostcapillary venulesLesionsPatientsWhealDamage ensuesImmunofluorescenceAngitisSkinNeutrophilsHistamine
1974
Microcirculation in Psoriatic Skin
Braverman I, Yen A. Microcirculation in Psoriatic Skin. Journal Of Investigative Dermatology 1974, 62: 493-502. PMID: 4823589, DOI: 10.1111/1523-1747.ep12681007.Peer-Reviewed Original ResearchMeSH KeywordsBiopsyCapillariesEpithelial CellsHumansMicrocirculationMicroscopy, ElectronModels, StructuralPsoriasisSkin
1973
The Multiple Lentigines Syndrome
Nordlund J, Lerner A, Braverman I, McGuire J. The Multiple Lentigines Syndrome. JAMA Dermatology 1973, 107: 259-261. PMID: 4685582, DOI: 10.1001/archderm.1973.01620170067018.Peer-Reviewed Original Research