Demonstration of Immune Complexes in Spontaneous and Histamine-Induced Lesions and in Normal Skin of Patients with Leukocytoclastic Angiitis
Braverman I, Yen A. Demonstration of Immune Complexes in Spontaneous and Histamine-Induced Lesions and in Normal Skin of Patients with Leukocytoclastic Angiitis. Journal Of Investigative Dermatology 1975, 64: 105-112. PMID: 123546, DOI: 10.1111/1523-1747.ep12510321.Peer-Reviewed Original ResearchConceptsHistamine-induced whealElectron-dense depositsImmune complexesUninvolved skinSpontaneous lesionsDirect immunofluorescenceImmune reactantsImmune complex pathogenesisImmune complex diseaseVessel wallLeukocytoclastic angiitisHistopathologic changesComplex pathogenesisLocal injectionNormal skinPostcapillary venulesLesionsPatientsWhealDamage ensuesImmunofluorescenceAngitisSkinNeutrophilsHistamine