TIM-1 and TIM-4 Glycoproteins Bind Phosphatidylserine and Mediate Uptake of Apoptotic Cells
Kobayashi N, Karisola P, Peña-Cruz V, Dorfman D, Jinushi M, Umetsu S, Butte M, Nagumo H, Chernova I, Zhu B, Sharpe A, Ito S, Dranoff G, Kaplan G, Casasnovas J, Umetsu D, DeKruyff R, Freeman G. TIM-1 and TIM-4 Glycoproteins Bind Phosphatidylserine and Mediate Uptake of Apoptotic Cells. Immunity 2007, 27: 927-940. PMID: 18082433, PMCID: PMC2757006, DOI: 10.1016/j.immuni.2007.11.011.Peer-Reviewed Original ResearchConceptsTIM-4TIM-1Apoptotic cellsT cell immunoglobulin mucin (TIM) proteinsPrevention of autoimmunityT cell activationGroup of receptorsDendritic cellsCell activationPeritoneal macrophagesMonoclonal antibodiesEfficient clearanceMouse macrophagesRecognition of phosphatidylserineMucin proteinKidney cellsPhagocytosisMacrophagesCellsPS bindingMediate uptakeAutoimmunityPhosphatidylserine